Results 231 to 240 of about 2,563,441 (411)

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

open access: yesAdvanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi   +8 more
wiley   +1 more source

Mitochondrial Maintenance in Skeletal Muscle. [PDF]

open access: yesCold Spring Harb Perspect Biol
de Smalen LM, Handschin C.
europepmc   +1 more source

The action of adrenaline on mammalian skeletal muscle

open access: green, 1948
G. L. Brown   +2 more
openalex   +2 more sources

Skeletal Muscle Hemangiomas [PDF]

open access: bronze, 1945
Raymond L. Evans   +2 more
openalex   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

open access: yesAdvanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang   +9 more
wiley   +1 more source

Effect of Ether Anesthesia on Human Skeletal Muscle Metabolism [PDF]

open access: bronze, 1959
DOROTHY H. HENNEMAN, LEHOY D. VANDAM
openalex   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

open access: yesAdvanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun   +15 more
wiley   +1 more source

Skeletal muscle

open access: yesRadiopaedia.org, 2021
D. Bell, J. Feger
semanticscholar   +1 more source

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