Results 121 to 130 of about 1,364 (146)

Stimulatory effects of needling and plasma on collagen synthesis in SKH-1 hairless mice

Journal of Physics D: Applied Physics, 2019
Abstract In this study, we demonstrate an effective skin therapy device based on the plasma generated nitric oxide (NO) and needling techniques. The NO generator was constructed based on the dielectric barrier discharge plasma and combined with a commercial needling device.
Jongkeun Yang, Sangjae So, Natraj Premkumar, Meejung Ahn, Suresh Rai, Ulugbek Shaislamov, Muhammad Waqar Ahmed, Chang-Hoon Han, Heonju Lee   +8 more
openaire   +1 more source

Dietary Lutein/Zeaxanthin Partially Reduces Photoaging and Photocarcinogenesis in Chronically UVB-Irradiated Skh-1 Hairless Mice

Skin Pharmacology and Physiology, 2007
Lutein and zeaxanthin are xanthophyll carotenoids with potent antioxidant properties protecting the skin from acute photodamage. This study extended the investigation to chronic photodamage and photocarcinogenesis. Mice received either a lutein/zeaxanthin-supplemented diet or a standard nonsupplemented diet.
S, Astner, A, Wu, J, Chen, N, Philips, F, Rius-Diaz, C, Parrado, M C, Mihm, D A, Goukassian, M A, Pathak, S, González   +9 more
openaire   +2 more sources

Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice

Toxicology and Applied Pharmacology, 2013
Lewisite is a potent chemical warfare arsenical vesicant that can cause severe skin lesions. Today, lewisite exposure remains possible during demilitarization of old ammunitions and as a result of deliberate use. Although its cutaneous toxicity is not fully elucidated, a specific antidote exists, the British anti-lewisite (BAL, dimercaprol) but it is ...
Stéphane, Mouret, Julien, Wartelle, Sandy, Emorine, Marine, Bertoni, Nina, Nguon, Cécile, Cléry-Barraud, Frédéric, Dorandeu, Isabelle, Boudry   +7 more
openaire   +2 more sources

Cyclooxygenase‐2 Inhibitor Nimesulide Blocks Ultraviolet B‐induced Photocarcinogenesis in SKH‐1 Hairless Mice^†

Photochemistry and Photobiology, 2008
AbstractCyclooxygenase‐2 (COX‐2) inhibition can inhibit UVB‐induced carcinogenesis in the skin. We have shown that COX‐2 is overexpressed in UVB‐induced squamous cell carcinomas (SCCs). Celecoxib, a specific inhibitor of COX‐2, blocks UVB‐induced papillomas and carcinomas in murine skin.
Xiuwei, Tang, Arianna L, Kim, Levy, Kopelovich, David R, Bickers, Mohammad, Athar   +4 more
openaire   +2 more sources

Immune related gene expression profiling of UVB‐induced photoaging skin in SKH‐1 hairless mice

The FASEB Journal, 2008
Ultraviolet (UV) irradiation is a major environmental hazard that leads to acute and chronic reactions in the skin. Chronic exposure to UV irradiation causes premature skin aging(photoaging), which is characterized clinically wrinkle, laxity, coarseness, mottled pigmentation, rough skin textures.
JUNG HUN JU, JK Lee, KH Sohn, JP Lee, JH Kim, CH Lim, SK Hong, IY Kim, JR Kim, SW Ock, SH Kim, Kui Lea Park   +11 more
openaire   +1 more source

Inhibitory effect of glycolic acid on ultraviolet‐induced skin tumorigenesis in SKH‐1 hairless mice and its mechanism of action

Molecular Carcinogenesis, 2001
AbstractGlycolic acid, an alpha‐hydroxy acid derived from fruit and milk sugars, has been used commonly as a cosmetic ingredient since it was discovered to have photoprotective and anti‐inflammatory effects and antioxidant effects on ultraviolet (UV)B–irradiated skin.
J T, Hong, E J, Kim, K S, Ahn, K M, Jung, Y P, Yun, Y K, Park, S H, Lee   +6 more
openaire   +2 more sources

Photochemoprotective Effect of Calluna vulgaris Extract on Skin Exposed to Multiple Doses of Ultraviolet B in SKH-1 Hairless Mice

Journal of Environmental Pathology, Toxicology and Oncology, 2012
UVB is a major cause of nonmelanoma skin cancer in humans. Photochemoprevention represents an important strategy in protecting the skin against the detrimental effects of ultraviolet B (UVB). We investigated the activity of Calluna vulgaris (Cv) delivered via a hydrogel on 3 main pathways (oxidative stress, inflammation, DNA damage) on skin exposed to ...
Elena Diana, Olteanu, Adriana, Filip, Simona, Clichici, Doina, Daicoviciu, Marcela, Achim, Ion Dan, Postescu, Pompei, Bolfa, Laura, Bolojan, Laurian, Vlase, Adriana, Muresan   +9 more
openaire   +2 more sources

Quercetin Prevents UV‐lnduced Local Immunosuppression, but Does Not Affect UV‐lnduced Tumor Growth in SKH‐1 Hairless Mice

Photochemistry and Photobiology, 1997
Abstract— Ultraviolet is thought to induce skin tumors by its dual activity as a mutagenic agent and a suppressor of cell‐mediated immunity. In the present study the effects of quercetin, a flavonoid‐containing compound, on carcinogenesis and immunosuppression were studied in SKH hairless mice exposed to suberythemal doses of UV for up to 17 weeks.
Steerenberg, P. A., Garssen, J., Dortant, P., Van De Vliet, H., Geerse, L., Verlaan, A. P J, Goettsch, W., Sontag, Y., Norval, M., Gibbs, N. K., Bueno-de-Mesquita, H. B., Van Loveren, H.   +11 more
openaire   +3 more sources

Determination of the maximal carcinoma/normal skin ratio after HpD or m-THPC administration in Hairless mice (SKH-1) by fluorescence spectroscopy

Anti-Cancer Drugs, 2000
The two major steps in our study on the treatment of skin carcinomas by photochemotherapy (PCT) were the development of a skin tumor model in Hairless mice by a chemical carcinogenesis and the use of fluorescence spectroscopy, a semi-quantitative and non-invasive method, in order to determine the time after i.p.
E, Bossu, J J, Padilla-Ybarra, D, Notter, C, Vigneron, F, Guillemin   +4 more
openaire   +2 more sources

Determination of Endogenous Porphyrins and the Maximal Hpd Tumor/Normal Skin Ratio in Skh-1 Hairless Mice by Light Induced Fluorescence Spectroscopy

Artificial Cells, Blood Substitutes, and Biotechnology, 1999
The treatment of skin tumors is an application of photochemotherapy (PCT) which involves an initial administration of a photosensitizer (PS) followed by irradiation with a light beam that causes the PS to produce cytotoxic oxygen species within the tumors.
E, Bossu, J J, Padilla, O, A'Amar, R M, Parache, D, Notter, C, Vigneron, F, Guillemin   +6 more
openaire   +2 more sources