Results 121 to 130 of about 2,203,706 (318)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Towards improved maternal health: Navigating non-compliance with integrated viral hepatitis B and malaria interventions among pregnant women in Bono East, Ghana.

Heliyon
Background: Effective management of viral hepatitis B (HBV) and malaria in pregnancy requires compliance with HBV vaccination, long-lasting insecticidal nets (LLINs), and intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-
Dennis Bardoe, Daniel Hayford, Robert Bagngmen Bio, Denis Dekugmen Yar, Ernest Osei, Ismail Coffie, Mohammed Zakaria, Francisca Serwaa Oppong, Fiave John Bosco, George Ahiaka, Enoch Owusu Yeboah, Samuel Mengyah, Frank Mengyah   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Skills@wlv.ac.uk

, 2013
Welcome to the skills development website from the University of Wolverhampton. All our guides (print, audio and video) are available under the Creative Commons Attribution-NonCommercial-ShareAlike CC BY-NC-SA license.
Skills Development Team
core  

Developing the information skills agenda [PDF]

, 2006
CELT Projects on Changing Practice Through Innovation and ResearchTechnological advances by the database creators of the late 60’s and early 70’s enabled the ‘information explosion’ to be managed and accessed.
Ordidge, Irene
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The role of skills from worklessness to sustainable employment with progression [PDF]

, 2011
This study is shaped by the recognition that while there has been a great deal of policy development around the transition from unemployment and inactivity to employment over the last decade, policy can still be informed about how best to nurture ...
Mitchell, B, Devins, D, Egdell, V, Nunn, A, Lindsay, C, Egdell, Valerie, Devins, David, Lindsay, Colin, Nunn, Alex, Mitchell, Ben, Bickerstaffe, Tim, Lindsay, Sue, McQuaid, Ronald, McQuaid, R, McQuaid, Ron, Bickerstaffe, T   +15 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Presentation skills - Face-to-face activities

, 2013
Handouts and resources for delivering a face-to-face session on presentation skills.
Skills@Library
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source