Results 161 to 170 of about 21,053,299 (356)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Prevalence and Correlates of Hepatitis B in Pregnancy: Evidence From a Cross‐Sectional Study in Bono East Region, Ghana

Health Science Reports
Background and Aims Hepatitis B virus (HBV) infection during pregnancy is associated with adverse maternal and neonatal outcomes. Although Ghana's national HBV prevalence is 8.36%, regional disparities are often underexplored.
Dennis Bardoe, Daniel Hayford, Robert Bagngmen Bio, Denis Dekugmen Yar   +3 more
doaj   +1 more source

Modeling students’ interest in mathematics: the role of self-efficacy, mathematics anxiety, cultural and societal perceptions, and relevance of mathematics

Frontiers in Education
PurposeThe purpose of this study is to determine the direct effect of self-efficacy (SEE), mathematics anxiety (MAA), cultural and societal perceptions (CSP), and relevance of mathematics (REM) on students’ interest in mathematics (SIM).Design ...
Samuel Kwaku Boadu, Francis Ohene Boateng, Benjamin Adu Obeng   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A scoping review of life skills development and transfer in emerging adults. [PDF]

Front Psychol, 2023
Tanious R, Gérain P, Jacquet W, Van Hoof E.   +3 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Employee demand for skills: evidence and policy review : UK Commission for Employment and Skills Research Report no. 3 [PDF]

, 2009
This report presents the results of a detailed review of evidence and policy relating to the factors that influence the engagement of the individual in skills development.
Dutton, Matthew, Johnson, Steve, Lindsay, Colin, McQuaid, Ronald, Pearson, Claire, Sawicki, Szymon   +5 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Learner guidance and support : models used and staff views of effects on retention [PDF]

, 2003
"This report provides the findings of the West of England Learning and Skills Research Network (WoE LSRN) project on Learner guidance and support: models used and staff views of effects on retention. The project’s aims were agreed after consultation with
Clay, Sara
core