Results 141 to 150 of about 21,053,299 (356)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Improving work organisation - the case for a regional action programme [PDF]
, 2005 A policy think piece to inform the development of the 2006 Regional Economic Strategy on how adoption of modern work organisation/high performance working practices could improve skills utilisation in the context of the 'low pay low skills equilibrium ...
Sisson, K
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Teachers’ conceptualization of validity and reliability in classroom assessment in Ghana
African Journal of Teacher EducationAssessment must be conducted so that the result is reliable and valid. However, in Ghana, standardised tests are not available for use by classroom teachers, therefore, classroom teachers depend on their little knowledge in conducting classroom ...
Ato Arhin, Abraham Yeboah
doaj +1 more source
Developing administrative skills [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2000 openaire +2 more sources
MMORPGs and Their Effect on Players [PDF]
, 2017 The purpose of this essay is to explore the popularity and effects of video games in the MMORPG genre. Games and play have been a part of human culture for an exceptionally long time, and in the recent decades video games have a become a large medium to ...
Manocha, Udit
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Construction skills development in the UK : transitioning between the formal and informal [PDF]
, 2008 Research reported here is part of a wider study that seeks to examine the practices involved in encouraging and enabling employers to engage with the skills development agenda.
Chan, Paul, Moehler, Robert
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source