Results 71 to 80 of about 2,559 (287)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Stepped Spillway Hydraulic Model Investigation

Tikrit Journal of Engineering Sciences, 2006
An experimental hydraulic model investigation was conducted to evaluate the performance of a stepped overflow spillway . The spillway tested has a standard ogee profile with continuous steps cut into a straight portion of downstream face from tangential ...
Jaafar Sadeq Maatooq
doaj   +1 more source

Numerical Study to Evaluate the Performance of Nonuniform Stepped Spillway Using ANSYS-CFX

Polytechnic Journal, 2020
The main features that attract hydraulic engineers for designing stepped spillways are their ability to lose a large portion of the flow energy and add or increase aeration to the flow naturally.
Shawnm M. Saleh, Sarhang M. Husain
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Oil Layer Flow around Skimming Vessels

Journal of the Society of Naval Architects of Japan, 1990
ABSTRACT The flow of an oil layer around an advancing skimming vessel was investigated theoretically on the following assumptions: (1) the oil layer is so thin that the velocity distribution is uniform over the depth; (2) there is no shear and tension at the oil-water interface; and (3) the density difference between oil and water is so small that the ...
Suzuki, Isao, Miki, Kenjiro, Yagi, Takanobu   +2 more
openaire   +3 more sources

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Computational investigation of hydraulic performance variation with geometry in gabion stepped spillways

Water Science and Engineering, 2019
Over recent years, there has been a clear increase in the frequency of reported flooding events around the world. Gabion structures offer one means of flood mitigation in dam spillways.
Dominic E. Reeve, Ali Adel Zuhaira, Harshinie Karunarathna   +2 more
doaj   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Empirical Modeling of Flow Characteristics in Stepped Spillways [PDF]

Journal of Applied Fluid Mechanics
Present comprehensive study integrates experimental analysis of geometrically different stepped spillway with empirical modeling to optimize uncertain flow conditions.
P. Dharmadhikari, S. Gandhi
doaj   +1 more source

Experimental study of transition and skimming flows on stepped spillways in rcc dams: qualitative analysis and pressure measurements [PDF]

, 2020
This paper is a presentation of an experimental facility used for analyzing the flow over the stepped spillway of an RCC dam. The technique of digitizing video sequences is applied in order to obtain a qualitative analysis of the hydraulic behavior of ...
Dolz, Jose, Juny, Martí
core