Results 51 to 60 of about 2,030 (258)
Advanced Science, EarlyView.An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao +18 more
wiley +1 more source
Methods for Predicting Bubble Size Distribution in Turbulent Flow
Water Resources ResearchGas bubbles are commonly observed in both natural and human‐made water systems, and their generation and distribution play pivotal roles in water quality and aquatic habitats.
Pengcheng Li +3 more
doaj +1 more source
Numerical analysis of jet-induced vortices in high-head stepped spillways with a PKW crest using the Omega–Liutex method [PDF]
AIP AdvancesThis study investigates the flow characteristics and energy dissipation mechanisms of a high-head stepped weir equipped with a piano key weir (PKW) crest, focusing on vortex structures along the flume steps.
Cong Trieu Tran, Cong Ty Trinh
doaj +1 more source
Advanced Science, EarlyView.Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao +21 more
wiley +1 more source
Oil Layer Flow around Skimming Vessels
Journal of the Society of Naval Architects of Japan, 1990 ABSTRACT The flow of an oil layer around an advancing skimming vessel was investigated theoretically on the following assumptions: (1) the oil layer is so thin that the velocity distribution is uniform over the depth; (2) there is no shear and tension at the oil-water interface; and (3) the density difference between oil and water is so small that the ...
Suzuki, Isao +2 more
openaire +3 more sources
Flow Pattern and Energy Dissipation in Stepped Spillways With Non-Uniform Step Height Using the ANSYS CFX Software [PDF]
مهندسی منابع آب, 2014 The use of stepped spillways has been increasingly on the rise due to their low cost and high efficiency. Hence, growing attention has been paid to the studies in this field by dam engineers; however, most of these studies have focused on the stepped ...
h. e, m. m
doaj
RBRH, 2020 The traditional approach for the hydrodynamic characterization of the flow down stepped spillways is through physical modeling, which is susceptible to scale effects and has limitations related to experimental apparatus, laboratory space and the spatial ...
Lucas Camargo da Silva Tassinari +4 more
doaj +1 more source
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source