Results 21 to 30 of about 775 (254)

Comparison of Energy Dissipation between Nappe and Skimming Flow Regimes on Stepped Chutes [PDF]

, 1994
For the last decades, stepped spillways have become a popular method for handling flood releases. The flow regime over a stepped chute can be either a nappe flow or skimming flow regime. The energy dissipation of both flow regimes are analysed.
Chanson, Hubert
core   +1 more source

Numerical investigation of alternating skimming flow over a stepped spillway

, 2021
This study aims to illustrate the influence of stepped spillway width on alternating skimming flow development. A computational fluid dynamics (CFD) model in Ansys Fluent® was established to simulate the flow over stepped spillways, using a volume of ...
Gafsi, Moustefa, Benmamar, Saâdia, Carvalho, Rita F., Kaouachi, Anouar, Lopes, Pedro   +4 more
core   +1 more source

Prediction of the transition nappe/skimming flow on a stepped channel [PDF]

Journal of Hydraulic Research, 1996
On a stepped channel, two distinct flow regimes may occur : nappe flow for low discharges and flat slopes, and skimming flow for larger flow rates. A simple analytical method to predict the onset of skimming flow is presented. The method is based upon the change of momentum direction at the impact of the jet on the downstream step.
openaire   +4 more sources

Characteristics of clustered particles in skimming flows on a stepped spillway [PDF]

, 2013
Air–water flows at hydraulic structures are commonly observed and called white waters. The free-surface aeration is characterised by some intense exchanges of air and water leading to complex air–water structures including some clustering. The number and
Chanson, Hubert, Sun, Simin
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A New Approach to Model Confined Suspensions Flows in Complex Networks: Application to Blood Flow [PDF]

, 2010
The modeling of blood flows confined in micro-channels or micro-capillary beds depends on the interactions between the cell-phase, plasma and the complex geometry of the network.
Plouraboué, Franck, Guibert, Romain, Fonta, Caroline   +2 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Methods for Predicting Bubble Size Distribution in Turbulent Flow

Water Resources Research
Gas bubbles are commonly observed in both natural and human‐made water systems, and their generation and distribution play pivotal roles in water quality and aquatic habitats.
Pengcheng Li, David Z. Zhu, Hang Wang, Rongcai Tang   +3 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source