Results 21 to 30 of about 206,532 (307)

Analytical Method Development and Dermal Absorption of Pyrogallol, a Hair Dye Ingredient

Toxics, 2022
Pyrogallol is an ingredient in hair dye. Its concentration in hair dye is managed at less than 2.0% in Korea. There have been no reports on the dermal absorption rate of pyrogallol.
Yu-Jin Kim, Hyang-Yeon Kim, Jung-Dae Lee, Hong-Yoon Kim, Jueng-Eun Im, Kyu-Bong Kim   +5 more
doaj   +1 more source

Race, pigmentation, and the human skin barrier—considerations for dermal absorption studies

Frontiers in Toxicology, 2023
A functional human skin barrier is critical in limiting harmful exposure to environmental agents and regulating the absorption of intentionally applied topical drug and cosmetic products.
Alec T. Salminen, Prashiela Manga, Luísa Camacho   +2 more
doaj   +1 more source

Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children

Pharmaceutics, 2022
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults.
Yejin Esther Yun, Daniella Calderon-Nieva, Abdullah Hamadeh, Andrea N. Edginton   +3 more
doaj   +1 more source

Improving Water Solubility and Skin Penetration of Ursolic Acid through a Nanofiber Process to Achieve Better In Vitro Anti-Breast Cancer Activity

Pharmaceutics
Woman’s breast cancer has always been among the top ten causes of cancer death, and nearly 2% to 5% of locally advanced breast cancers develop a fungating breast wound.
Hsuan Fu, Tzu-Hui Wu, Chih-Peng Ma, Feng-Lin Yen   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Shaving area of unwanted hair before laser operation is useful in cosmetic procedure: A simulation study

Journal of Dermatology and Dermatologic Surgery, 2015
In laser dermatology applications, the process of photon absorption, the reflectance and the thermal energy diffusion in the target tissue and its surrounding tissue during laser irradiation is crucial.
Farhad H. Mustafa, Mohamad S. Jaafar
doaj   +1 more source

Skin Barrier Function in Infants: Update and Outlook

Pharmaceutics, 2022
A good understanding of infant skin should provide a rationale for optimum management of the health of this integument. In this review, we discuss the skin barrier function of infants, particularly with reference to the use of diapers and baby wipes. The
Annisa Rahma, Majella E. Lane
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro and ex-vivo evaluation of topical formulations designed to minimize transdermal absorption of Vitamin K1. [PDF]

PLoS ONE, 2018
Topical application of Vitamin K1 has been demonstrated to effectively treat papulopustular skin rash, a serious and frequently encountered side effect of Epidermal Growth Factor Inhibitors (EGFRIs).
Ramina Nabiee, Barent Dubois, Laura Green, Ajay Sharma, Siu Fun Wong, Hamidreza Montazeri Aliabadi   +5 more
doaj   +1 more source