Results 91 to 100 of about 446,329 (344)

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

3D Monte Carlo radiation transfer modelling of photodynamic therapy [PDF]

, 2015
We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.The effects of ageing and skin type on Photodynamic Therapy (PDT) for ...
Brown, C Tom A, Campbell, Catherine Louise, Christison, C., Moseley, H., Valentine, Ronan Martin, Wood, Kenny   +5 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Development of a Global Subjective Skin Aging Assessment score from the perspective of dermatologists

BMC Research Notes, 2019
Objective Several skin aging assessment scales exist but no standard scale is widely used. Dermatologists may be the most appropriate persons for skin assessment but their perceptions regarding the signs of skin aging are unexplored.
Punnapath Buranasirin, Krit Pongpirul, Jitlada Meephansan   +2 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

New Synthetic Endocannabinoid as Anti-Inflammaging Cosmetic Active: an In Vitro Study on a Reconstructed Skin Model [PDF]

, 2019
Endocannabinoids have been recently appointed as interesting cosmetic actives in regulating inflammaging, a state of chronic low-grade inflammation, known for being involved in many senescence\u2019s manifestations, included skin aging.
Caviola, E, Galizia, G and Baratto G, Meloni, M, Semenzato, A   +3 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Integrated analysis of facial microbiome and skin physio-optical properties unveils cutotype-dependent aging effects

Microbiome
Background Our facial skin hosts millions of microorganisms, primarily bacteria, crucial for skin health by maintaining the physical barrier, modulating immune response, and metabolizing bioactive materials. Aging significantly influences the composition
Chuqing Sun, Guoru Hu, Liwen Yi, Wei Ge, Qingyu Yang, Xiangliang Yang, Yifan He, Zhi Liu, Wei-Hua Chen   +8 more
doaj   +1 more source