Results 81 to 90 of about 1,545,710 (301)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Integrated analysis of facial microbiome and skin physio-optical properties unveils cutotype-dependent aging effects

Microbiome
Background Our facial skin hosts millions of microorganisms, primarily bacteria, crucial for skin health by maintaining the physical barrier, modulating immune response, and metabolizing bioactive materials. Aging significantly influences the composition
Chuqing Sun, Guoru Hu, Liwen Yi, Wei Ge, Qingyu Yang, Xiangliang Yang, Yifan He, Zhi Liu, Wei-Hua Chen   +8 more
doaj   +1 more source

Osteolineage cells ablation promotes skin aging phenotypes via dysregulated bone marrow macrophages

iScience
Summary: Clinical evidence links bone loss to skin thinning during aging, yet the causal role of bone in skin regulation remains unclear. Here, we show that the partial ablation of osteolineage cells induces skin aging, manifested by dermal thinning ...
Sen-Yao Zhang, Zhi-Kai Zheng, Fang Ye, Bing-Qi Wang, Shu-Hui Fan, Jun-Jie Gao, Yi-Dan Pang, Yi-Gang Huang   +7 more
doaj   +1 more source

Skinomics: A New Toolbox to Understand Skin Aging

, 2016
In recent years, we have witnessed the dawn of “omics” technologies, approaches that comprehensively deal with the entire genome, transcriptome, proteome, microbiome, etc.
Miroslav Blumenberg, Komine, Mayumi, Blumenberg, Miroslav, Sidra Younis, Mayumi Komine, Marjana Tomic-Canic, Younis, Sidra, Tomic-Canic, Marjana   +7 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

[Coalition for Aging LGBT Pamphlet]

Pamphlet from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

THE CONTROL OF SOME HORMONES RELATING TO CUTANEOUS AGING: MECHANISMS, MANIFESTATIONS, AND MANAGEMENT

Tạp chí Sức khỏe và Lão hóa (Journal of Health and Aging)
To summarize current evidence on the interaction between endocrine factors and skin aging, with a focus on the role of hormones and endocrine pathways.
Huynh Thi Xuan Tam
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review

Frontiers in Physiology
The interplay between the microbes and the skin barrier holds pivotal significance in skin health and aging. The skin and gut, both of which are critical immune and neuroendocrine system, harbor microbes that are kept in balance.
Yu Ri Woo, Hei Sung Kim
doaj   +1 more source