Results 31 to 40 of about 164,444 (304)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

New Insights Into the Skin Microbial Communities and Skin Aging

Frontiers in Microbiology, 2020
Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging.
Zichao Li, Xiaozhi Bai, Tingwei Peng, Xiaowei Yi, Liang Luo, Jizhong Yang, Jiaqi Liu, Yunchuan Wang, Ting He, Xujie Wang, Huayu Zhu, Hongtao Wang, Ke Tao, Zhao Zheng, Linlin Su, Dahai Hu   +15 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Mechanisms of skin aging

Iatreia, 2017
Skin aging is an inevitable biological phenomenon of human life that results from either the age-dependent decline of cell function (intrinsic aging) or from cumulative exposure to external harmful influences (extrinsic aging).
Mesa-Arango, Ana Cecilia, Flórez-Muñoz, Sindy Viviana, Sanclemente, Gloria   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mechanism of action and therapeutic effects of oxidative stress and stem cell-based materials in skin aging: Current evidence and future perspectives

Frontiers in Bioengineering and Biotechnology, 2023
Aging is associated with multiple degenerative diseases, including atherosclerosis, osteoporosis, and Alzheimer’s disease. As the most intuitive manifestation of aging, skin aging has received the most significant attention.
Huan Qian, Yihan Shan, Ruicheng Gong, Danfeng Lin, Mengwen Zhang, Chen Wang, Lu Wang   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Skin Aging

Skin Aging
Aging is an integral part of every person’s life. All organs and systems go through a stage of gerontological changes, the skin is the organ whose age-related changes are most noticeable. The total life expectancy of the population is growing, but when reaching the age of 50 years, structural changes in the skin are already inevitable, first of all ...
Maria Sifaki, Stella Baliou, Sabine Kruger-Krasagakis, Polytimi Sidiropoulou, Dimitra Nikolopoulou, Aristidis Tsatsakis   +5 more
  +5 more sources

Alpha-Lipoic Acid Supplementation Restores Early Age-Related Sensory and Endothelial Dysfunction in the Skin

Biomedicines, 2022
Many changes characterize skin aging, and the resulting dysfunctions still constitute a real challenge for our society. The aim of this study was to compare the skin aging of two rat strains, Wistar and Brown Norway (BN), considered as “poorly aging” and
Anne-France de Bengy, Johanna Decorps, Lisa S. Martin, Aurélie Pagnon, Fabien P. Chevalier, Dominique Sigaudo-Roussel, Bérengère Fromy   +6 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source