Results 51 to 60 of about 1,545,710 (301)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mechanisms of skin aging

Iatreia, 2017
Skin aging is an inevitable biological phenomenon of human life that results from either the age-dependent decline of cell function (intrinsic aging) or from cumulative exposure to external harmful influences (extrinsic aging).
Mesa-Arango, Ana Cecilia, Flórez-Muñoz, Sindy Viviana, Sanclemente, Gloria   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Sea Cucumber Collagen Peptides Exert an Anti-Skin Aging Effect by Inhibiting Endoplasmic Reticulum Stress in Fibroblasts

Foods
Skin aging is a complex biological process triggered by intrinsic and extrinsic factors, causing structural and functional deterioration, and its mitigation is a priority in cosmetology and functional food science.
Rui Mi, Biyi Chen, Juncai Leng, Wei Zhao, Shan Gao, Jingwei Jiang, Jing Lan, Zunchun Zhou   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems

Microsystems & Nanoengineering
Skin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process.
Yu Yao, Zilin Zhang, Jing Zhang, Yuan Gao, Xiaoran Li, Keyu Yang, Nuo Si, Zaozao Chen, Zhongze Gu, Ningbei Yin   +9 more
doaj   +1 more source

Role of Nutritional Elements in Skin Homeostasis: A Review

Biomolecules
Skin aging is the most prominent phenotype of human aging and is the result from the interaction of genetic and environmental factors. Improving skin aging is essential for maintaining the normal physiological function of the skin and the mental health ...
Nansong Jiang, Tao Quan, Ran Li, Yaoxing Chen, Ting Gao   +4 more
doaj   +1 more source

New Insights Into the Skin Microbial Communities and Skin Aging

Frontiers in Microbiology, 2020
Although it is well-known that human skin aging is accompanied by an alteration in the skin microbiota, we know little about how the composition of these changes during the course of aging and the effects of age-related skin microbes on aging.
Zichao Li, Xiaozhi Bai, Tingwei Peng, Xiaowei Yi, Liang Luo, Jizhong Yang, Jiaqi Liu, Yunchuan Wang, Ting He, Xujie Wang, Huayu Zhu, Hongtao Wang, Ke Tao, Zhao Zheng, Linlin Su, Dahai Hu   +15 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source