Results 41 to 50 of about 434,035 (288)

Surgery-for-life:Aging, sexual fitness and self-management in Brazil [PDF]

, 2014
This article draws on ethnographic fieldwork on plastic surgery to explore tensions in aging norms and ideals for women in Brazil.  I situate my analysis in relation to debates about a “de-chronologized life course.”  Some scholars argue that the life ...
Edmonds, Alexander
core   +3 more sources

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles. [PDF]

, 2019
ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated ...
Burney, Waqas A, Chodur, Gwen M, Foolad, Negar, Newman, John W, Rybak, Iryna, Sivamani, Raja K, Steinberg, Francene M, Vaughn, Alexandra R   +7 more
core   +1 more source

Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]

, 2019
Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
core  

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

Klotho mice: a novel wound model of aged skin. [PDF]

, 2014
BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly.
Yamashita, Ken, Yamauchi, Makoto, Yotsuyanagi, Takatoshi, Young, David M   +3 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice

Journal of Pharmaceutical Analysis
The “gut-skin” axis has been proved and is considered as a novel therapy for the prevention of skin aging. The antioxidant efficacy of oligomannonic acid (MAOS) makes it an intriguing target for use to improve skin aging.
Ting Gao, Yixuan Li, Xiaoyu Wang, Fazheng Ren   +3 more
doaj   +1 more source

Aspects of Facial Contrast Decrease with Age and Are Cues for Age Perception [PDF]

, 2013
Age is a primary social dimension. We behave differently toward people as a function of how old we perceive them to be. Age perception relies on cues that are correlated with age, such as wrinkles.
Mauger, Emmanuelle, Porcheron, Aurelie, Russell, Richard   +2 more
core   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source