Results 71 to 80 of about 1,669,596 (254)

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Calcium and Skin Barrier

, 2015
The epidermal permeability barrier is established late in fetal development. Indeed, the Ca(2+) gradient is crucial to the normal development of skin. Human epidermis displays a characteristic calcium gradient, with lower calcium levels in the basal and ...
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Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction [PDF]

, 2008
Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene.
Ussar, S, Moritz Widmaier, Fässler, R., Genzel-Boroviczeny, O., Fässler, R, Rognoni, E, Moser, M., Markus Moser, Christian Harrer, Harrer, C., Emanuel Rognoni, Moser, Markus, Reinhard Fässler, Genzel-Boroviczeny, Orsolya, Siegfried Ussar, Ussar, Siegfried, Genzel-Boroviczeny, O, Faessler, Reinhard, Widmaier, M, Harrer, C, Rognoni, E., Harrer, Christian, Widmaier, M., Orsolya Genzel-Boroviczeny, Moser, M, Ussar, S., Widmaier, Moritz, Rognoni, Emanuel   +27 more
core   +2 more sources

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review

Frontiers in Physiology
The interplay between the microbes and the skin barrier holds pivotal significance in skin health and aging. The skin and gut, both of which are critical immune and neuroendocrine system, harbor microbes that are kept in balance.
Yu Ri Woo, Hei Sung Kim
doaj   +1 more source

Particulate matter causes skin barrier dysfunction

JCI Insight, 2021
The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In this study, the effects of PM2.5 on filaggrin (FLG) and skin barrier function were investigated in vitro and in ...
Byung Eui Kim, Jihyun Kim, Elena Goleva, Evgeny Berdyshev, Jinyoung Lee, Kathryn A. Vang, Un Ha Lee, SongYi Han, Susan Leung, Clifton F. Hall, Na-Rae Kim, Irina Bronova, Eu Jin Lee, Hye-Ran Yang, Donald Y.M. Leung, Kangmo Ahn   +15 more
doaj   +1 more source

Anti-microbial Peptides (AMPs) in Skin Barrier

, 2010
As the name implies, role of anti-microbial peptides (AMPs) has been mainly considered as providing anti-microbial defense against exogenous infections of bacteria, fungi and virus.
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Skin barrier disruption by acetone: observations in a hairless mouse skin model [PDF]

, 2009
To disrupt the barrier function of the skin, different in vivo methods have been established, e.g., by acetone wiping or tape-stripping. In this study, the acetone-induced barrier disruption of hairless mice was investigated in order to establish a ...
Ponec, M., Joke A. Bouwstra, Dep Farmaceutische wetenschappen, Oudshoorn, M.H.M., Maria Ponec, Marion H. M. Oudshoorn, Robert Rissmann, Wim E. Hennink, Hennink, W.E., Advanced drug delivery systems/drug targeting, Bouwstra, J.A., Rissmann, R.   +11 more
core   +2 more sources

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

The relationship between the skin microecology and the skin barrier

Pifu-xingbing zhenliaoxue zazhi
With the development of metagenomics sequencing and spatial transcriptomics, the door to the "microscopic world" of the skin surface has gradually been opened, and the "inhabitants" on the "habitat" of the skin have gradually become well-known.
LIN Tianyi, CHEN Jiaoquan, OU Shanshan, WU Weihong, ZOU Hui, CHEN Ziyan, PENG Liqian, CHEN Quan, LI Huaping, ZHU Huilan   +9 more
doaj   +1 more source