Results 71 to 80 of about 1,761,530 (296)

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin

Frontiers in Medicine
BackgroundThe skin barrier plays a crucial role in protecting our body against external agents. Disruption of this barrier’s function leads to increased susceptibility to infections and dermatological diseases.
Manon Barthe, Manon Barthe, Laure-Alix Clerbaux, Jean-Paul Thénot, Véronique M. Braud, Hanan Osman-Ponchet   +5 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

History-dependent switch-like differentiation of keratinocytes in response to skin barrier damage.

PLoS Computational Biology
The epidermis is formed by layers of keratinocytes with increasing levels of differentiation towards the outer skin called skin barrier, which protects our body from environmental stressors and dehydration.
Elisa Domíguez-Hüttinger, Eliezer Flores-Garza, José Luis Caldú-Primo, Harley Day, Abihail Roque Ramírez, Reiko J Tanaka   +5 more
doaj   +1 more source

The relationship between skin function, barrier properties, and body-dependent factors

, 2017
Background: Skin is a multilayer interface between the body and the environment, responsible for many important functions, such as temperature regulation, water transport, sensation, and protection from external triggers.
Dąbrowska, A.K., Spano, F., Spencer, N.D., Adlhart, C., S. Derler, N.D. Spencer, Rossi, R.M., R.M. Rossi, C. Adlhart, Derler, S., A.K. Dąbrowska, F. Spano, Spano F, Derler, S. (author), Spano, F. (author), Spencer, N.D. (author), Adlhart, C. (author), Derler S, Rossi RM, Spencer ND, Rossi, R.M. (author), Dąbrowska AK, Adlhart C, Dąbrowska, A.K. (author)   +23 more
core   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Herbal medicines that benefit epidermal permeability barrier function

Dermatologica Sinica, 2015
Epidermal permeability barrier function plays a critical role in regulating cutaneous functions. Hence, researchers have been searching for effective and affordable regimens to enhance epidermal permeability barrier function.
Lizhi Hu, Huibin Man, Peter M. Elias, Mao-Qiang Man   +3 more
doaj   +1 more source

Calcium and Skin Barrier

, 2015
The epidermal permeability barrier is established late in fetal development. Indeed, the Ca(2+) gradient is crucial to the normal development of skin. Human epidermis displays a characteristic calcium gradient, with lower calcium levels in the basal and ...
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