Results 11 to 20 of about 17,976 (211)

Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Nature Communications, 2023
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament ...
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke   +19 more
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The Biology of Varicella-Zoster Virus Replication in the Skin

Viruses, 2022
The replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus.
Cristina Tommasi, Judith Breuer
doaj   +1 more source

Delayed Diagnosis of Pemphigus Vulgaris Initially Presenting as an Oral Ulcer: A Case Report

Journal of Nepal Medical Association, 2022
Pemphigus vulgaris is a rare autoimmune mucocutaneous blistering disease clinically presenting as vesicles, bullae, and erosion and histologically characterized by suprabasal split and acantholysis.
Ramesh Lamichhane, Saroj Chaudhary
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Staphylococcal Infections and Neonatal Skin: Data from Literature and Suggestions for the Clinical Management from Four Challenging Patients

Antibiotics, 2023
Staphylococcal infections in neonates might be associated with skin blistering since early antibiotic therapy has been shown to limit infection spread and positively influence outcomes; therefore, neonatologists should be aware of these conditions.
Domenico Umberto De Rose, Flaminia Pugnaloni, Ludovica Martini, Iliana Bersani, Maria Paola Ronchetti, Andrea Diociaiuti, May El Hachem, Andrea Dotta, Cinzia Auriti   +8 more
doaj   +1 more source

Case Report: Diagnostic and Therapeutic Challenges in Severe Mechanobullous Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2022
Collagen VII is the main constituent of the anchoring fibrils, important adhesive structures that attach the epidermis to the dermal extracellular matrix.
Franziska Schauer, Alexander Nyström, Manfred Kunz, Stefanie Hübner, Sarah Scholl, Ioannis Athanasiou, Svenja Alter, Judith Fischer, Cristina Has, Dimitra Kiritsi   +9 more
doaj   +1 more source

Immunofluorescence testing in the diagnosis of autoimmune blistering diseases: overview of 10-year experience [PDF]

Anais Brasileiros de Dermatologia, 2014
BACKGROUND: Immunofluorescence testing is an important tool for diagnosing blistering diseases. OBJECTIVE: To characterize the immunofluorescence findings in patients diagnosed with autoimmune blistering skin diseases.
Samia Trigo Arbache, Tarsila Gasparotto Nogueira, Lívia Delgado, Denise Miyamoto, Valéria Aoki   +4 more
doaj   +1 more source

A Review of Acquired Autoimmune Blistering Diseases in Inherited Epidermolysis Bullosa: Implications for the Future of Gene Therapy

Antibodies, 2021
Gene therapy serves as a promising therapy in the pipeline for treatment of epidermolysis bullosa (EB). However, with great promise, the risk of autoimmunity must be considered. While EB is a group of inherited blistering disorders caused by mutations in
Payal M. Patel, Virginia A. Jones, Christy T. Behnam, Giovanni Di Zenzo, Kyle T. Amber   +4 more
doaj   +1 more source

Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice

Orphanet Journal of Rare Diseases, 2013
Background Bullous pemphigoid is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies directed mainly to the hemidesmosomal component collagen XVII.
Chiriac Mircea Teodor, Licarete Emilia, Sas Alexandra Gabriela, Rados Andreea Maria, Lupan Iulia, Chiriac Anca Mirela, Speth Hilda, Pop-Vancia Vlad, Domsa Iacob, Sesarman Alina, Popescu Octavian, Sitaru Cassian   +11 more
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Collagen XVII Processing and Blistering Skin Diseases

Acta Dermato-Venereologica, 2020
Collagen XVII (COL17) is a hemidesmosomal transmembrane protein in the skin, which, in several autoimmune blistering skin diseases, may be targeted by autoantibodies.
Wataru Nishie
doaj   +1 more source

Staphylococcal Scalded Skin Syndrome in Healthy Infant

Majalah Kedokteran Andalas, 2022
Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis ...
Anggia Perdana Harmen
doaj   +1 more source