Results 21 to 30 of about 17,976 (211)

Kindler′s syndrome: A tale of two siblings

Indian Journal of Dermatology, 2016
Kindler′s syndrome (KS) is a rare inherited skin disease characterized by acral blistering, photosensitivity, progressive poikiloderma, and cutaneous atrophy along with different types of mucosal involvement. We hereby report KS in two siblings. The case
Navya Handa, Dilip Kachhawa, Vinod Kumar Jain, Pankaj Rao, Anupam Das   +4 more
doaj   +1 more source

Experimental models of dermatological diseases

Бюллетень сибирской медицины, 2019
This review presents analysis of experimental models of atopic dermatitis, psoriasis, skin symptoms of autoimmune systemic connective tissue diseases, and blistering skin diseases.
O. N. Sergeeva, M. B. Aksenenko, Yu. F. Fefelova, E. Yu. Sergeeva, T. G. Ruksha   +4 more
doaj   +1 more source

Bullous Pemphigoid and Other Pemphigoid Dermatoses

Medicina, 2021
The pemphigoid family of dermatoses is characterized by autoimmune subepidermal blistering. The classic paradigm for pemphigoid, and the most common member, is bullous pemphigoid.
Valeryia Pratasava, Vikram N. Sahni, Aishwarya Suresh, Simo Huang, Abhirup Are, Sylvia Hsu, Kiran Motaparthi   +6 more
doaj   +1 more source

Mouse Models for Blistering Skin Disorders

Dermatology Research and Practice, 2010
Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between ...
Radhika Ganeshan, Jiangli Chen, Peter J. Koch   +2 more
doaj   +1 more source

Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by in vivo CRISPR-Cas9 delivery using adenoviral vectors

Molecular Therapy: Methods & Clinical Development, 2022
Recessive dystrophic epidermolysis bullosa, a devastating skin fragility disease characterized by recurrent skin blistering, scarring, and a high risk of developing squamous cell carcinoma is caused by mutations in COL7A1, the gene encoding type VII ...
Marta García, Jose Bonafont, Jesús Martínez-Palacios, Rudan Xu, Giandomenico Turchiano, Stina Svensson, Adrian J. Thrasher, Fernando Larcher, Marcela Del Rio, Rubén Hernández-Alcoceba, Marina I. Garín, Ángeles Mencía, Rodolfo Murillas   +12 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Lower Extremity Salvage in the Setting of Bullous Pemphigoid Exacerbation: A Case Report

Plastic and Reconstructive Surgery, Global Open, 2021
Summary:. Bullous pemphigoid is an autoimmune blistering disease where patients suffer from painful bullae, often covering large portions of the skin and requiring management with immune-suppression.
Samara E. Pollock, MD, Shauna M. Rice, BS, Sarah D. Ferree, MD, Jonathan Friedstat, MD, MPH, Kyle Eberlin, MD, Arianne S Kourosh, MD MPH   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites

FEBS Open Bio, 2020
Type VII collagen is an extracellular matrix protein, which is important for skin stability; however, detailed information at the molecular level is scarce.
Jan M. Gebauer, Florian Flachsenberg, Cordula Windler, Barbara Richer, Ulrich Baumann, Karsten Seeger   +5 more
doaj   +1 more source