Results 91 to 100 of about 640,542 (312)

Targeting CLEC4E in immunosuppressive tumour‐associated macrophages via BET inhibition

Clinical and Translational Medicine
Background Immunosuppressive tumour‐associated macrophages (TAMs) represent a promising target for cancer immunotherapy; however, existing TAM‐directed therapies have shown limited clinical efficacy. C‐type lectin domain family 4 member E (CLEC4E), a pro‐
Mengting Liao, Kexin Long, Liang Dong, Zhuo Li, Wenhua Wang, Rui Hu, Yangyi Zhang, Juan Su, Wu Zhu, Xiang Chen, Mingzhu Yin   +10 more
doaj   +1 more source

Sunlight and Skin Cancer

BioMed Research International, 2001
It is well known that chronic exposure to ultraviolet (UV) radiation present in sunlight is responsible for the induction of most nonmelanoma skin cancer (NMSC) in humans. Wavelengths in the UV-B (290–320 nm) region of the solar spectrum are absorbed into the skin, producing erythema, burns, and eventually skin cancer.
openaire   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation

Cell Discovery
The role of CD8+ tissue-resident memory T (CD8+ TRM) in inflammation is well established. However, the mechanisms by which CD8+ TRM cells are activated in tissues have remained elusive.
Rundong Jiang, Zhiqin Fang, Yutong Wang, Bo Huang, Junkun Liu, Lam C. Tsoi, Rachael Bogle, Zongbo Zhang, Yehong Kuang, Xin Li, Liang Dong, Liping Jin, Johann E. Gudjonsson, Mingzhu Yin, Xiang Chen   +14 more
doaj   +1 more source

Emerging 2D Materials and Their Hybrid Nanostructures for Label‐Free Optical Biosensing: Recent Progress and Outlook

Advanced Functional Materials, EarlyView.
This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

422 An open-label, multicenter, phase 1/2 clinical trial of RP1, an enhanced potency oncolytic HSV, combined with nivolumab: updated results from the skin cancer cohorts

, 2020
Mark R. Middleton, Francesca Aroldi, Joseph J. Sacco, Mohammed Milhem, Brendan D. Curti, Ari VanderWalde MBioeth, Scott Baum, Adel Samson, Anna C. Pavlick, Jason Chesney, Jiaxin Niu, Terence D. Rhodes, Tawnya L. Bowles, Robert M. Conry, Anna Olsson‐Brown, Douglas Laux, Howard L. Kaufman, Praveen K. Bommareddy, Alex Deterding, Selda Samakoglu, Robert S. Coffin, Kevin J. Harrington   +21 more
openalex   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Three Cases of Skin Cancer Arising from Irradiated Skin.

, 1995
Kayoko YASUNO, Atsushi Nakamura, Yoshihiro Maekawa, Reiko Nogami   +3 more
openalex   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source