Results 91 to 100 of about 1,239,936 (299)

A Deep Dive into Understanding Tumor Foci Classification using Multiparametric MRI Based on Convolutional Neural Network

, 2020
Deep learning models have had a great success in disease classifications using large data pools of skin cancer images or lung X-rays. However, data scarcity has been the roadblock of applying deep learning models directly on prostate multiparametric MRI (
Carver, Eric, Chetty, Indrin, Elshaikh, Mohamed, Feldman, Aharon, Hearshen, David, Janic, Branislava, Lee, Joon, Liu, Chang, Movsas, Benjamin, Pantelic, Milan, Wen, Ning, Zong, Weiwei   +11 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A composite score of serum cytokines enables early identification of patients at high risk for irAEs under immune checkpoint inhibition

Frontiers in Immunology
BackgroundImmune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced skin cancers. However, potentially severe and irreversible immune-related adverse events (irAEs) represent a major clinical challenge.
Nina Flatt, Antje Walter, Corinna Kochanek, Maximilian Beikirch, Viola K. DeTemple, Yenny Angela, Imke von Wasielewski, Ralf Gutzmer, Katrin Schaper-Gerhardt, Katrin Schaper-Gerhardt   +9 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment

Frontiers in Oncology, 2018
Despite enormous international efforts, skin melanoma is still a major clinical challenge. Melanoma takes a top place among the most common cancer types and it has one of the most rapidly increasing incidences in many countries around the world.
Hildur Helgadottir, Hildur Helgadottir, Iara Rocha Trocoli Drakensjö, Iara Rocha Trocoli Drakensjö, Ada Girnita, Ada Girnita   +5 more
doaj   +1 more source

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Nature Communications, 2020
Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets ...
Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan   +14 more
doaj   +1 more source

Dying for a tan : explaining intentions to use sunscreen with the theory of planned behaviour, threats to appearance and mortality, and the theory of terror management : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

, 2003
Skin cancer has become one of the most prevalent forms of cancer throughout the world (Arthey & Clarke, 1995), with New Zealand leading the world in both melanoma-related deaths and incidences. It has been indicated that 80 per cent of skin cancers could
Mills, Katharine Elizabeth
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms

Frontiers in Oncology
BackgroundExtramammary Paget’s disease (EMPD) is a rare cutaneous malignancy, commonly affecting the external genitalia and perianal area of the elderly with unclear pathogenesis.
Long Jiang, Long Jiang, Xiaoxiang Xu, Xiaoxiang Xu, Guorong Yan, Guorong Yan, Guorong Yan, Yuhao Wu, Yuhao Wu, Yuhao Wu, Ningyuan Xi, Ningyuan Xi, Yongxian Lai, Yongxian Lai, Guolong Zhang, Guolong Zhang, Guolong Zhang, Yeqiang Liu, Yeqiang Liu   +18 more
doaj   +1 more source