Results 161 to 170 of about 7,017,143 (393)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

open access: yesAdvanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer   +10 more
wiley   +1 more source

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
Platinum‐Copper bimetallic nanoparticles may evolve depending on their synthesis under tumor microenvironment conditions and play a dual role as chemotherapeutic agents after releasing Cu ions and as near infrared photothermal agents with the Pt‐rich remaining frames.
Jose I. Garcia‐Peiro   +7 more
wiley   +1 more source

Topical TYK2 inhibitor ameliorates psoriasis‐like dermatitis via the AKT‐SP1‐NGFR‐AP1 pathway in keratinocytes

open access: yesClinical and Translational Medicine
Introduction Tyrosine kinase 2 (TYK2)‐dependent cytokine signalling is integral to the pathogenesis of psoriasis. While BMS‐986165, a highly selective TYK2 inhibitor, has recently been approved for oral treatment of psoriasis, its therapeutic potential ...
Zhiqin Fang   +5 more
doaj   +1 more source

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

open access: yesAdvanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er   +8 more
wiley   +1 more source

The Mortality from Cancer of the Skin and Lip in Certain Occupations [PDF]

open access: bronze, 1949
M Atkin   +4 more
openalex   +1 more source

The progress and prospects of targeting the adenosine pathway in cancer immunotherapy

open access: yesBiomarker Research
Despite the notable success of cancer immunotherapy, its effectiveness is often limited in a significant proportion of patients, highlighting the need to explore alternative tumor immune evasion mechanisms.
Yuying Yang   +7 more
doaj   +1 more source

Human–computer collaboration for skin cancer recognition

open access: yesNature Network Boston, 2020
P. Tschandl   +18 more
semanticscholar   +1 more source

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