Results 171 to 180 of about 641,694 (264)

Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancer. [PDF]

Histochem Cell Biol
Wanner M, Brunner A, Ortner D, Tripp CH, Hermann M, Neurauter S, Del-Frari B, Nguyen VA, Stoitzner P.   +8 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

SkinFormer: a hybrid vision transformer and ConvNeXtV2 approach for skin cancer detection and segmentation. [PDF]

Sci Rep
Fu Y, Guo C.
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Biomaterials for Improving Skin Penetration in Treatment of Skin Cancer. [PDF]

J Funct Biomater
Secci D, Urquhart A, Bekiaris V, Qvortrup K.   +3 more
europepmc   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Effects of Ozone-Depleting Substances on Ultraviolet Radiation and Skin Cancer Rates in Australia and the United States of America. [PDF]

Geohealth
Lee-Taylor J, Hu Z, Kyle J, Karipidis K, Henderson S, Landolfi R, Tasich CM, Madronich S.   +7 more
europepmc   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Mohs versus wide local excision: Highlighting the need to define optimal surgical strategies for hidradenocarcinoma

JAAD Case Reports
Madalyn Bland South, BA, Alfredo Siller, Jr., MD, Matthew DaCunha, MD, Stephen Tyring, MD, PhD, Brett M. Coldiron, MD   +4 more
doaj   +1 more source

Revealing key biomarkers and molecular mechanisms associated with di(2-ethylhexyl) phthalate in skin cancer. [PDF]

Front Mol Biosci
Zhou H, Wang H, Xie K, Ma H, Wu R, Ban D, Wang J, Sun Z, Wei J, Zhou D.   +9 more
europepmc   +1 more source