Results 11 to 20 of about 350,517 (216)

Internal Migration and Leprosy in Shanghai from 2000 to 2019: an Epidemiological Study of New Cases

Acta Dermato-Venereologica, 2021
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Massive internal migration from rural to urban areas poses new challenges for leprosy control in Shanghai, China.
Jianyu Zhu, Chao Shi, Degang Yang, Yeqiang Liu, Jia Chen, Meiping Ye, Chunjie Liao, Zhichun Jing, Pingyu Zhou   +8 more
doaj   +1 more source

Tricyclazole alleviates Fonsecaea pedrosoi-induced immune suppression of neutrophils by inhibiting DHN-melanin biosynthesis

Frontiers in Cellular and Infection Microbiology
IntroductionChromoblastomycosis (CBM) is a chronic cutaneous infection caused by dematiaceous fungi, characterized by therapeutic challenges such as difficulty in pathogen clearance and high recurrence rates. Fonsecaea pedrosoi (F.
Chunjiao Zheng, Wei Li, Yuanyuan Wang, Lulu Li, Linan Ni, Xiaoping Liu, Jingwen Tan, Lianjuan Yang, Qian Yu   +8 more
doaj   +1 more source

Comparative analysis and optimization of multi-model artificial intelligence for microscopic detection of fungal structures in superficial fungal infections

Frontiers in Cellular and Infection Microbiology
BackgroundSuperficial fungal infections present a growing threat to global public health. Traditional diagnostic techniques, including microscopy and culture, are time-consuming and subjective, often limiting diagnostic accuracy. Artificial intelligence (
Mei Liu, Wenjing He, Linan Ni, Lulu Li, Yuling Tang, Jingwen Tan, Lianjuan Yang   +6 more
doaj   +1 more source

DeepCas12a: a hybrid deep learning framework for accurate AsCas12a efficiency prediction from sequence and epigenetic information

BMC Genomics
CRISPR-Cas12a (Cpf1) offers distinct advantages for genome editing due to its flexible, T-rich PAM recognition. However, variable cleavage efficiency—modulated by sequence context and epigenetic features—remains a challenge, with existing tools facing ...
Yiming Shi, Junkai Yin, Shurui Ning, Jinling Yuan, Degang Yang, Guohui Chuai   +5 more
doaj   +1 more source

Phenotypic and metabolic characterization of an ADH2 deletion mutant associated with reduced fluconazole susceptibility in Candida albicans

Frontiers in Cellular and Infection Microbiology
IntroductionAlcohol dehydrogenases (ADHs) participate in fungal carbon metabolism and redox homeostasis, but the contribution of ADH2 to virulence-associated phenotypes and fluconazole response in Candida albicans (C.
Chunjiao Zheng, Wenjing He, Chang Su, Lulu An, Jingwen Tan, Jingwen Tan, Lianjuan Yang, Lianjuan Yang   +7 more
doaj   +1 more source

Update on Dermoscopy and Infectious Skin Diseases

Dermatology Practical & Conceptual, 2019
Nowadays, dermoscopy is a global worldwide diffuse diagnostic tool supporting clinicians in their daily hard task of correct orientation among dermatological diseases.
Vincenzo Piccolo
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Automatic fluorescence microscopic image analyzer: a novel AI-based tool for early diagnosing superficial fungal infections

BMC Infectious Diseases
Background Superficial fungal infections (SFIs) are highly prevalent globally, affecting approximately 20–25% of the population. Their diverse and often non-specific clinical manifestations necessitate accurate and timely laboratory diagnosis ...
Wenjing He, Chunjiao Zheng, Lianjuan Yang, Jingwen Tan   +3 more
doaj   +1 more source

Granular parakeratosis associated with the use of laundry sanitizers containing benzalkonium chloride: a case report

Frontiers in Allergy
BackgroundGranular parakeratosis (GP) is a rare benign inflammatory dermatosis that preferentially involves the axillae and other intertriginous, friction-prone skin sites and typically presents with pruritic erythema and scaling.
Meizhen Fang, Meizhen Fang, Jingqiu Zhang, Jingqiu Zhang, Zilu Qu, Zilu Qu, Bin Hu, Bin Hu, Yun Xia, Yun Xia, Liang Zhang, Liang Zhang, Liuqing Chen, Liuqing Chen   +13 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source