Results 21 to 30 of about 337,852 (256)

Skin diseases in patients with primary psychiatric conditions: A hospital based study

Journal of Epidemiology and Global Health, 2019
Background: Although the relationship between skin diseases in patients with primary psychiatric conditions is important for patient management, studies on this issue are limited.
Nayera H. Moftah, Abeer M. Kamel, Hussein M. Attia, Mona Z. El-Baz, Hala M. Abd El–Moty   +4 more
doaj   +1 more source

DeepCas12a: a hybrid deep learning framework for accurate AsCas12a efficiency prediction from sequence and epigenetic information

BMC Genomics
CRISPR-Cas12a (Cpf1) offers distinct advantages for genome editing due to its flexible, T-rich PAM recognition. However, variable cleavage efficiency—modulated by sequence context and epigenetic features—remains a challenge, with existing tools facing ...
Yiming Shi, Junkai Yin, Shurui Ning, Jinling Yuan, Degang Yang, Guohui Chuai   +5 more
doaj   +1 more source

“Online survey of COVID-19 immunization and infection in patients with systemic juvenile idiopathic arthritis and adult-onset still’s disease.”

Pediatric Rheumatology Online Journal, 2023
Background Patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) have been under-represented in studies about safety of the COVID-19 immunization. We aimed to inquire about the safety and tolerability of COVID-
Mariana Correia Marques, Subrata Paul, Carol Lake, Ly-Lan Bergeron, Rashmi Sinha, Luciana Peixoto, Marinka Twilt, Michael J. Ombrello   +7 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

HIV self-testing in Singapore is safe, feasible and acceptable: Results from a pilot implementation project

Annals, Academy of Medicine, Singapore
The Joint United Nations Programme on human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) (UNAIDS) has set an ambitious goal to end AIDS by 2030 by achieving the 95-95-95 testing and treatment targets by 2025, where 95% of all ...
Chen Seong Wong, Koon Wee Benson Yeo, Sally Low, Fikri Alkhatib, Felicia Huimei Hong, Chiaw Yee Choy, Sophia Archuleta   +6 more
doaj   +1 more source

The effects of climate change on infectious diseases with cutaneous manifestations

International Journal of Women's Dermatology, 2021
Background: Anthropogenic climate change affects the burden of infectious diseases via several interconnected mechanisms. In recent years, there has been greater awareness of the ways in which climate-sensitive infectious diseases pose a growing threat ...
Sarah J. Coates, MD, Scott A. Norton, MD, MPH, MSc   +1 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Automatic fluorescence microscopic image analyzer: a novel AI-based tool for early diagnosing superficial fungal infections

BMC Infectious Diseases
Background Superficial fungal infections (SFIs) are highly prevalent globally, affecting approximately 20–25% of the population. Their diverse and often non-specific clinical manifestations necessitate accurate and timely laboratory diagnosis ...
Wenjing He, Chunjiao Zheng, Lianjuan Yang, Jingwen Tan   +3 more
doaj   +1 more source

Successful treatment of refractory classic juvenile pityriasis rubra pilaris with adalimumab in a 4-year-old girl: a case report

Frontiers in Immunology
BackgroundClassic juvenile pityriasis rubra pilaris (PRP) (Griffiths type III) is a rare inflammatory papulosquamous dermatosis that is often refractory to conventional topical and systemic treatments.
Jianlan Zhang, Jianlan Zhang, Yuyue Zuo, Yuyue Zuo, Ruili Jiang, Ruili Jiang, Yun Xia, Yun Xia, Jinbo Chen, Jinbo Chen   +9 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source