Results 81 to 90 of about 797,461 (297)

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee   +19 more
wiley   +1 more source

Clinical and pathological characteristics of multiple superficial basal cell carcinoma: A report of 6 cases

open access: yesPifu-xingbing zhenliaoxue zazhi
[Objective] To investigate the characteristics of multiple superficial basal cell carcinoma. [Methods] The clinical data from 6 patients with multiple superficial basal cell carcinoma were retrospectively analyzed.
HE Pingxiu   +4 more
doaj   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden   +15 more
wiley   +1 more source

Factors associated with a better treatment efficacy among psoriasis patients: a study based on decision tree model and logistic regression in Shanghai, China

open access: yesBMC Public Health
Background Many effective therapies for psoriasis are being applied in clinical practice in recent years, however, some patients still can’t achieve satisfied effect even with biologics.
Fanlingzi Shen   +7 more
doaj   +1 more source

Clinical manifestations of primary syphilis in homosexual men

open access: yesBrazilian Journal of Infectious Diseases
At the beginning of a new millennium, syphilis incidence has been increasing worldwide, occurring primarily among men who have sex with men (MSM).
Milan Bjekić   +2 more
doaj   +1 more source

Diseases of the Skin [PDF]

open access: yesAnnual Review of Medicine, 1958
Stephen Rothman, and A L Lorincz
openaire   +3 more sources

Naftalan in Diseases of the Skin [PDF]

open access: yesThe American Journal of the Medical Sciences, 1901
n ...
openaire   +2 more sources

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