Results 101 to 110 of about 2,027,719 (303)

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Jullien, D., Langley, RGB, Dedrick, R., Prinz, Jörg Christoph, Joshi, A., Natta, P., Dummer, W.   +7 more
core   +1 more source

Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective

Biomedicines
(1) Background: Autoimmune pancreatitis (AIP) is mainly treated with steroids. Using an AIP mouse model, we investigated two potential alternatives, the transforming growth factor-β-activated kinase 1 inhibitor, takinib, and the Janus kinase inhibitor ...
Ottavia Agrifoglio, Anika Kasprick, Natalie Gross, Marc Wahlig, Emilia Kauffold, Aline Woitas, Artem Vorobyev, Luise Ehlers, Ralf J. Ludwig, Katja Bieber, Robert Jaster   +10 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Determinants of Satisfaction with Medical Care for Hidradenitis Suppurativa: Results from a Multicentre Survey in Germany

Dermatology and Therapy
Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with considerable physical and psychosocial distress. Recent studies have reported low levels of satisfaction among patients with HS regarding the medical care ...
Kerstin Wolk, Dagmar Wilsmann-Theis, Nessr Abu Rached, Giorgia Cugno, Rotraut Moessner, Christian Kromer, Falk G. Bechara, Katharina Assaf, Wiebke K. Peitsch, Lisa C. Schneider, Andreas Happ, Valentina Siddi, Diana Kubitzki, Durdana Groß, Markus Friedrich, Staffan Vandersee, Khusru Asadullah, Sylke Schneider-Burrus, Georgios Kokolakis, Robert Sabat   +19 more
doaj   +1 more source

Psoriasis as a barrier disease

Dermatologica Sinica, 2015
Skin is equipped with a barrier function, in particular, to prevent invasion of pathogens. Skin barrier is composed of a mechanical barrier, a permeability barrier, and innate and adaptive immunity barriers.
Shigetoshi Sano
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +2 more sources

Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model

Frontiers in Microbiology, 2018
This study was designed to evaluate the protective effect of ethanol extract (SEL001) isolated from a potent probiotic strain Lactobacillus sakei proBio-65 on imiquimod (IMQ)-induced psoriasis-like skin inflammation in a mouse model.
Irfan A. Rather, Vivek K. Bajpai, Yun Suk Huh, Young-Kyu Han, Eijaz A. Bhat, Jeongheui Lim, Woon K. Paek, Yong-Ha Park   +7 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation

, 2018
International audienceAccumulation of large-scale mitochondrial DNA (mtDNA) deletions and chronic, subclinical inflammation are concomitant during skin aging, thus raising the question of a causal link.
Baris, Olivier, Weiland, Daniela, Neuhaus, Johannes, F G, Tobin, Desmond, J., Niessen, Carien, M, Holzer, Tatjana, Brachvogel, Bent, Hornig-Do, Hue-Tran, Neuhaus, Johannes F.G., Wiesner, Rudolf, J   +9 more
core   +1 more source