Acute and subacute repeated oral toxicity study of fragmented microplastics in Sprague-Dawley rats
Ecotoxicology and Environmental Safety, 2021 Polypropylene (PP) is the second most highly produced plastic worldwide, and its microplastic forms are found in water and food matrices. However, the effects of PP microplastics on human health remain largely unknown.
Jinsik Kim +6 more
doaj +1 more source
Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris. [PDF]
, 2015 Acne vulgaris is a common and chronic skin disease, and is a frequent source of morbidity for affected patients. Treatment of acne vulgaris is often difficult due to the multifactorial nature of this disease.
Eichenfield, Lawrence F, Nguyen, Tuyet A
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Evaluation of dermal irritation and skin sensitization due to vitacoxib
Toxicology Reports, 2017 The prediction of side-effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs
Jianzhong Wang +7 more
doaj +1 more source
Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1% [PDF]
, 2012 Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders.
Ayres JW +30 more
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Molecules, 2022 This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxicity
Karolina Słoczyńska +5 more
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Skin irritants of Euphorbia fortissima [PDF]
Journal of Pharmacy and Pharmacology, 1975 Abstract By means of a combination of partition and chromatographic methods six irritant constituents were isolated from the fresh latex of Euphorbia fortissima. Compounds A-D were di-esters of the common parent diterpene 12-deoxyphorbol, and compounds E and F were mono-esters of the same diterpene.
A D Kinghorn, Fred J. Evans
openaire +3 more sources
ACUTE DERMAL IRRITATION AND SKIN SENSITIZATION STUDY OF MESOPOROUS ANTIBACTERIAL BIOACTIVE GLASS MICROSPHERE IMPREGNATED SURGICAL COTTON GAUZE DRESSING MATERIAL ON RABBITS AND GUINEA PIGS [PDF]
Exploratory Animal and Medical Research: A study was undertaken to evaluate the skin sensitization and acute dermal irritation of Mesoporous antibacterial bioactive glass microsphere impregnated non-woven surgical cotton gauze (MABGmscg) dressings on shaved rabbits and guinea pigs. This study
Debolina Dattaray +4 more
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TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment [PDF]
Iranian Journal of Veterinary Medicine, 2019 Background: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and eye irritation/corrosion, and skin sensitization according to the guideline for Organization for Economic
Seyedeh Maedeh Jafari +4 more
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Body scrub containing Virgin Coconut Oil, coffee grounds (Coffea arabica Linn) and carbon active coconut shell (Activated carbon Cocos nucifera L) as a moisturiser and a skin brightener [PDF]
Scripta Medica, 2021 Introduction: Virgin Coconut Oil (VCO) contains a lot of medium chain fatty acids. VCO combined with coffee grounds (Coffea arabica Linn) and activated carbon (Activated carbon Cocos nucifera L) has the potential to form a preparation that can moisturise
Desi Eka Putri +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2006 Major local adverse reactions in the nicotine patches are skin reactions. To assess the skin reaction of PHK-301p, a newly developed nicotine patch, we conducted a phase I study that consisted of 2 parts: a skin irritation test (48-h closed patch test ...
Shin Irie +6 more
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