Results 261 to 270 of about 31,339 (306)
Some of the next articles are maybe not open access.
Effect of permeation enhancers and organic acids on the skin permeation of indapamide
International Journal of Pharmaceutics, 2008The aim of present study was to investigate the transdermal properties of indapamide and to explore the efficacy of various permeation enhancers and organic acids with regard to the percutaneous absorption of indapamide. Permeation experiments were performed in vitro, using rat abdominal skin as a barrier. In the permeation studies, 2-chamber diffusion
Changshun, Ren +5 more
openaire +2 more sources
SMGA gels for the skin permeation of haloperidol
Journal of Controlled Release, 2005Small molecule gelling agent (SMGA) gels were developed using the gelator GP-1 in the solvents, namely, isostearyl alcohol (ISA) and propylene glycol (PG), to deliver haloperidol through the skin. The concentrations of the drug, haloperidol, the enhancer, farnesol and the gelator, GP-1 are 3 mg/ml, 5% (w/v) and 5% (w/v), respectively.
Kang, L. +5 more
openaire +2 more sources
Permeation of Steroids through Human Skin
Journal of Pharmaceutical Sciences, 1995The permeabilities of many steroids through human skin have been previously measured and reported in the literature. Analysis of these data reveals that significant discrepancies exist between the measurements of Scheuplein et al. and those of other groups.
M E, Johnson, D, Blankschtein, R, Langer
openaire +2 more sources
In Vitro–In Vivo Correlation in Skin Permeation
Pharmaceutical Research, 2013In vitro skin permeation studies have been used extensively in the development and optimisation of delivery of actives in vivo. However, there are few reported correlations of such in vitro studies with in vivo data. The aim of this study was to investigate the skin permeation of a model active, niacinamide, both in vitro and in vivo.Conventional ...
D, Mohammed +3 more
openaire +2 more sources
In vitro permeation of levothyroxine across the skin
International Journal of Pharmaceutics, 2008The aim of this work was to investigate the in vitro transdermal permeation characteristics of sodium levothyroxine, in view of its topical application. Permeation experiments were performed in vitro, using rabbit ear skin as barrier. At the end of the experiments levothyroxine retained in the skin was extracted and quantified by HPLC. The formulations
PADULA, Cristina +2 more
openaire +3 more sources
Journal of Pharmaceutical Sciences, 2003
In previous studies (Yoneto et al., 1995. J Pharm Sci 84:312-317; Kim et al., 1992. Int J Pharm 80:17-31; and Warner et al., 2001. J Pharm Sci 90:1143-53), the transport enhancing effects of four homologous series of enhancers-the n-alkanols, 1-alkyl-2-pyrrolidones, 1,2-alkanediols, and N,N-dimethylalkanamides - on the transport of steroidal permeants ...
Ning, He +4 more
openaire +2 more sources
In previous studies (Yoneto et al., 1995. J Pharm Sci 84:312-317; Kim et al., 1992. Int J Pharm 80:17-31; and Warner et al., 2001. J Pharm Sci 90:1143-53), the transport enhancing effects of four homologous series of enhancers-the n-alkanols, 1-alkyl-2-pyrrolidones, 1,2-alkanediols, and N,N-dimethylalkanamides - on the transport of steroidal permeants ...
Ning, He +4 more
openaire +2 more sources
2017
Chemical compounds which may contact the skin include chemicals such as pesticides used against cockroaches and mosquitoes, repellents put into drawers, and topically applied therapeutic drugs and cosmetics. Plasticizers contained in building materials, endocrine disrupting chemicals (environmental hormones), volcanic ash, and radioactive materials may
openaire +1 more source
Chemical compounds which may contact the skin include chemicals such as pesticides used against cockroaches and mosquitoes, repellents put into drawers, and topically applied therapeutic drugs and cosmetics. Plasticizers contained in building materials, endocrine disrupting chemicals (environmental hormones), volcanic ash, and radioactive materials may
openaire +1 more source
A Random Walk Model of Skin Permeation
Risk Analysis, 2002A new mathematical model for permeability of chemicals in aqueous vehicle through skin is presented. The rationale for this model is to represent diffusion by its fundamental molecular mechanism, i.e., random thermal motion. Diffusion is modeled as a two‐dimensional random walk through the biphasic (lipid and corneocyte) stratum corneum (SC).
openaire +2 more sources
Exploration of skin permeation mechanism of frusemide with proniosomes
Die Pharmazie, 2009The present study explored the transdermal permeation enhancing mechanism of non-ionic surfactant vesicles (proniosomes) of frusemide across rat skin. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), activation energy and histological examination were carried out to study the mode of action of the optimized ...
Azeem, A., Ahmad, F. J., Talegaonkar, S.
openaire +2 more sources
HPTLC method to study skin permeation of acylovir
Journal of Pharmaceutical and Biomedical Analysis, 2000A new simple, rapid and selective high performance thin layer chromatography (HPTLC) method is developed for the quantitation of acyclovir during in vitro skin permeation studies. Separation of guinea pig skin proteins and acyclovir was achieved by employing a mobile phase consisting of chloroform-methanol-ammonia (15:9:4, v/v/v) on precoated silica ...
S S, Dubhashi, P R, Vavia
openaire +2 more sources