Results 271 to 280 of about 31,339 (306)
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Transdermal permeation of neutral molecules by skin electroporation
Journal of Controlled Release, 1998Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold.
R, Vanbever, M A, Leroy, V, Préat
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In vitro skin permeation techniques
Journal of Controlled Release, 1992Abstract This paper reviews various techniques used to assess permeation of drugs into and through skin under in vitro conditions. There have been a wide variety of diffusion cells designed for in vitro measurement of skin permeation. These cells have generally been designed in one of two ways: side-by-side (bichambers) and vertical in vivo mimic ...
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Overcoming the Skin Permeation Barrier: Challenges and Opportunities
Current Pharmaceutical Design, 2015Stratum corneum (SC), the outermost layer of the skin, constitutes an excellent protective physiological barrier, and is the main challenge in transdermal drug delivery. Many approaches have been used to enhance the penetration of drugs through this layer, covering passive and active methods or the combination of both.
Carla, Vitorino +2 more
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Preparation of curcuminoid niosomes for enhancement of skin permeation
Die Pharmazie, 2011Curcuminoids (curcumin, desmethoxycurcumin, and bisdesmethoxycurcumin) are major bioactive substances found in turmeric (Curcuma longa L.) extracts and possess antioxidant, anti-inflammatory, antimicrobial and anticancer properties. In this study, curcuminoid niosomes prepared with a series of Span non-ionic surfactants were developed to enhance the ...
N, Rungphanichkul +3 more
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Studies of the skin permeation of lipophilic drugs: paclitaxel.
Die Pharmazie, 2007The objective of this investigation was to develop and validate skin permeation methodology for a highly lipophilic drug with respect to sink conditions and intactness of barrier during the course of experiment, using water permeation and trans epidermal water loss as tools.
Khandavilli, S., Panchagnula, R.
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Skin Morphology and Permeation Pathway Through the Skin
2017A thorough understanding of skin morphology is essential before discussing skin penetration/permeation by chemical compounds. As explained in many textbooks, skin is made up of the epidermis, dermis, and hypodermis (or subcutis), which is layered under the dermis, as shown in Fig. 1.1.
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A Personal View of Skin Permeation (1960-2013)
Skin Pharmacology and Physiology, 2013I want to thank Mike Roberts for arranging this issue of the journal and Annette Bunge and Richard Guy for reviewing this paper. This is, first, a history of my introduction to the field of skin permeability, and then an attempt to recall (with the inaccuracies that implies) the highlights of my research (1960-1975) on skin permeation, and finally a ...
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Permeation of Chemicals Through the Skin
1986An overall risk/benefit analysis relative to the use of chemical protective clothing for protection from potentially harmful chemicals must ultimately consider the barrier effectiveness of the skin to the chemicals in question. For example, there may be cases in which some permeation of chemical through the clothing is tolerable if the skin itself is ...
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Sunscreens : implications of their skin permeation
The human use of sunscreens is now a wide-spread practice alleviating the damage incurred from over-exposure to solar radiation. In normal use, sunscreens contain relatively high concentrations of active chemical ingredients which are applied to large areas of skin.openaire +2 more sources