Results 141 to 150 of about 1,642,164 (380)

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

open access: yesAdvanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang   +11 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

open access: yesAdvanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun   +8 more
wiley   +1 more source

A comparative study of an advanced skin imaging system in diagnosing facial pigmentary and inflammatory conditions

open access: yesScientific Reports
Visual assessment, while the primary method for pigmentation and erythema evaluation in clinical practice, is subjective, time-consuming, and may lead to variability in observations among clinicians. Objective and quantitative techniques are required for
Yu-Wen Huang   +3 more
doaj   +1 more source

Focus on African diversity confirms complexity of skin pigmentation genetics

open access: yesGenome Biology, 2018
Renewed focus on African populations confirms the complexity of skin pigmentation genetics, and suggests future directions for pigmentation research.
Tina Lasisi, Mark D. Shriver
doaj   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

open access: yesAdvanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li   +11 more
wiley   +1 more source

Dynamic changes in the skin transcriptome for the melanin pigmentation in embryonic chickens

open access: yesPoultry Science
: Dermal hyperpigmentation stands out among the various skin pigmentation phenotypes in chickens, where most other pigmentation variants affect feather color and patterning predominantly. Despite numerous black chicken breeds worldwide, only a select few
Dong Leng   +8 more
doaj   +1 more source

Multiple arterial embolization from left atrial myxoma in a Maltese boy [PDF]

open access: yes, 1994
Atrial myxoma is rare in adults and even rarer in children. In this article the author describes. The presentation may be with embolic, obstructive or constitutional symptoms, which may be dramatic and life-threatening.
Elliott, Martin, Vassallo Agius, Paul
core  

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

open access: green, 2021
Varvara Kanti   +16 more
openalex   +1 more source

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