Results 111 to 120 of about 121,797 (299)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1% [PDF]

, 2012
Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders.
Ayres JW, Borelli C, Brown PH, C. Schöllmann, C. Willers, Cornell RC, Dumas KJ, Faergemann J, H.C. Korting, Haigh JM, Hoffmann K, Hughes J, Katz HI, Kerscher MJ, Kirkland R, Koivukangas V, Korting HC, Korting HC, Korting HC, Korting HC, Kulhalli P, Medansky RS, Olsen EA, Poulsen J, Prakash A, Proksch E, Sequira J, Surber C, W. Wigger-Alberti, Wiedersberg S, Wilkinson SM   +30 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input [PDF]

, 2014
Descending controls of spinal nociceptive processing play a critical role in the development of inflammatory hyperalgesia. Acute peripheral nociceptor sensitization drives spinal sensitization and activates spino–supraspinal–spinal loops leading to ...
Andrew, Asante, Bajic, Blake, Boada, Bridget M. Lumb, Campbell, Chillingworth, Clarke, Cook, Cook, Davis, DeFelice, Djouhri, Djouhri, Dogrul, Donaldson, Du, Dunham, Fields, Green, Guan, Harris, Horiguchi, Howorth, Hughes, Hylden, Iadarola, Ikeda, Jeong, Kauppila, Kocher, Koerber, Kwok, Latremoliere, Leem, Leith, Liu, Lucy F. Donaldson, Lynn, Magerl, Mantyh, Mantyh, McMullan, McMullan, McMullan, Meyer, Meyer, Miki, Millan, Millan, Oliva, Ossipov, Ossipov, Paalzow, Palazzo, Pertovaara, Pertovaara, Provitera, Przewłocki, Reed, Ren, Ren, Richard P. Hulse, Robert A. R. Drake, Sandrini, Schouenborg, Sivilotti, Soignier, Stanfa, Størkson, Suzuki, Takano, Terayama, Tsuruoka, Tsuruoka, Tsuruoka, Tyce, Vanegas, Vasquez, Wang, Westlund, Wiesenfeld-Hallin, Woolf, Yeomans, Yoshimura, You, Yu, Zhang, Ziegler   +89 more
core   +2 more sources

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Profile of sensitization to allergens in children with atopic dermatitis assisting to Allergology Service of University Hospital, Nuevo Leon, Mexico

Revista Alergia México, 2015
Background: Sensitization to allergens in atopic dermatitis patients is a risk factor for developing asthma and allergic rhinitis in the future, as well as an aggravating factor in the course of the disease. Recent studies have attributed the activity of
Adrián Yong-Rodríguez, Alejandra Macías-Weinmann, Samuel Palma-Gómez, Alfredo Arias-Cruz, Rafael Pérez-Vanzzini, José Julio Gutiérrez-Mujica, Sandra Nora González-Díaz   +6 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Frontiers in Toxicology
Introduction: Skin sensitization, which leads to allergic contact dermatitis, is a key toxicological endpoint with high occupational and consumer prevalence.
Zhengxi Wei, Tuan Xu, Judy Strickland, Li Zhang, Yuhong Fang, Dingyin Tao, Anton Simeonov, Ruili Huang, Nicole C. Kleinstreuer, Menghang Xia   +9 more
doaj   +1 more source