Results 111 to 120 of about 69,829 (286)

Induction of skin sensitization is augmented in Nrf2-deficient mice

, 2013
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization ...
Gremmer, Eric R., van Loveren, Henk, Vermeulen, Jolanda P., Ezendam, Janine, van der Veen, Jochem W.   +4 more
core   +1 more source

Toxicity evaluation of metsulfuron-methyl, nicosulfuron, and methoxyfenozide as pesticides in Indonesia

Open Agriculture
Pesticides are substances widely used to control or eliminate pests, including weeds, insects, and other harmful organisms. Agricultural pesticides, in particular, must meet specific safety and quality standards before being marketed.
Natawigena Wahyu Daradjat, Rifasta Muhammad Ilfadry, Susanto Agus, Wilar Gofarana, Suhandi Cecep   +4 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Skin exposure promotes a Th2-dependent sensitization to peanut allergens

, 2014
Sensitization to foods often occurs in infancy, without a known prior oral exposure, suggesting that alternative exposure routes contribute to food allergy.
Maleki, Soheila J., Soheila J. Maleki, Hugh A. Sampson, Galina Grishina, Benedé, Sara, Sampson, Hugh A., Goswami, Ritobrata, M. Cecilia Berin, Dunkin, David, Sara Benedé, David Dunkin, Kirsi M. Järvinen, Tordesillas, Leticia, Leticia Tordesillas, Ritobrata Goswami, Grishina, Galina, Järvinen, Kirsi M., Berin, M. Cecilia   +17 more
core   +2 more sources

Skin Sensitizers in Cosmetics and Skin Care Products

Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 2010
Cosmetics are defined as "articles with mild action on the human body, which are intended to be applied to the human body through rubbing, sprinkling or other methods, aiming to clean, beautify and increase the attractiveness, alter the appearance or to keep the skin or hair in good condition (The Pharmaceutical Affairs Law: Article 2)." Consequently ...
openaire   +3 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Anti-hapten antibodies in response to skin sensitization.

, 2015
Whereas T lymphocyte (T cell) activation is the key event in the acquisition of skin sensitization and subsequent elicitation of allergic contact dermatitis, the humoral component of immune responses to organic contact allergens has received little ...
Helen Singleton, Gavin Maxwell, Williams, Jason, Kimber, Ian, Jason Williams, Maxwell, Gavin, Gellatly, Nichola, Ian Kimber, Rebecca J. Dearman, Amy Popple, Singleton, Helen, Popple, Amy, Dearman, Rebecca J, Nichola Gellatly, Friedmann, Peter S, Peter S. Friedmann   +15 more
core   +1 more source

Epidermal cytokines and skin sensitization hazard.

, 1994
The induction phase of skin sensitization is associated with the passage of antigen-bearing Langerhans cells (LC) from the epidermis to the draining lymph nodes.
Cumberbatch, M, Kimber, I
core   +1 more source

Skin Sensitivity to Cetrimide [PDF]

Occupational and Environmental Medicine, 1949
C N D, CRUICKSHANK, J R, SQUIRE
openaire   +2 more sources