Results 121 to 130 of about 69,829 (286)

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms

Allergy, Asthma & Clinical Immunology
Background The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases patients’ costs. The objective of this study was to determine the culprit allergen in dual or triple-sensitized patients
Mohammad Hassan Bemanian, Raheleh Shokouhi Shoormasti, Saba Arshi, Mahsa Jafari, Sima Shokri, Morteza Fallahpour, Mohammad Nabavi, Fatemeh Zaremehrjardi   +7 more
doaj   +1 more source

Redefining Crystalline Silicon: Unlocking New Horizons in Transparent and Flexible Photovoltaics

Advanced Energy Materials, EarlyView.
Crystalline silicon is presented as a platform for transparent and flexible photovoltaics. This review article outlines design principles for optical strategies to fabricate transparent silicon solar cells, mechanical strategies that mitigate silicon brittleness, and emerging concepts such as singlet‐fission spectral conversion and tandem architectures,
Kangmin Lee
wiley   +1 more source

Factors Influencing the Induction Phase of Skin Sensitization

, 2003
The primary purpose of this review is to consider the factors that confer on chemicals the ability to induce skin sensitization and allergic contact dermatitis.
Dearman, Rebecca J., Kimber, Ian
core   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Skin Sensitization of Epoxyaldehydes: Importance of Conjugation

, 2013
Structure-activity relationship (SAR) models are important tools for predicting the skin sensitization potential of new compounds without animal testing.
Karlberg, Ann-Therese,, Hagvall, Lina,, Delaine, Tamara,, Luthman, Kristina,, Rudbäck, Johanna,   +4 more
core   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Skin Sensitization of Epoxyaldehydes: Importance of Conjugation

, 2016
Structure–activity relationship (SAR) models are important tools for predicting the skin sensitization potential of new compounds without animal testing.
Tamara Delaine (1273521), Kristina Luthman (802421), Johanna Rudbäck (1957588), Ann-Therese Karlberg (1734097), Lina Hagvall (1734103)   +4 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Immunoregulation of skin sensitization and regulatory T cells

, 2012
It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways.
Travis, Mark A., Dearman, Rebecca J., Ian Kimber, Stefan F. Martin, Rebecca J. Dearman, Mark A. Travis, Martin, Stefan F., Kimber, Ian   +7 more
core   +1 more source