Results 51 to 60 of about 69,829 (286)

Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity

, 1993
Twenty organic Salmonella mutagens, seven of which (including benzo[a]pyrene) are established skin carcinogens, and one of which (2-chloroethanol) is a well-defined noncarcinogen to skin, have been evaluated for skin-sensitizing activity using the local ...
Dearman, R. J., Ashby, J., Kimber, I., Hilton, J., Callander, R. D.   +4 more
core   +3 more sources

Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens

, 2009
BACKGROUND Allergy diagnosis needs to be improved in patients suffering from pollen polysensitization due to the existence of possible confounding factors in this type of patients.
Barber, Domingo, Rodriguez, R., Davila, I., Lombardero, M., Salcedo Duran, Gabriel, Colas, C., Torre, F. de la, Villalba, M., Antepara, I., Tabar, I.A., Vidal, C.   +10 more
core   +2 more sources

Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. [PDF]

, 2014
INTRODUCTION: The hypothesis that paracetamol, one of the most widely used medicines, may increase the risk of asthma and allergic disease is of obvious importance but prospective cohort data looking at dose and timing of exposure are lacking. OBJECTIVE:
Amberbir, Alemayehu, John Britton, Gail Davey (4462069), Andrea Venn, Medhin, Girmay, Girmay Medhin (347685), Britton, John, Alemayehu Amberbir (95491), Alemayehu Amberbir, Hanlon, Charlotte, Charlotte Hanlon, Andrea Venn (347686), John Britton (70864), Gail Davey (155158), Gail Davey, Charlotte Hanlon (291709), Venn, Andrea, Girmay Medhin, Davey, Gail   +18 more
core   +1 more source

SENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGION

Педиатрическая фармакология, 2013
Study of sensitization spread is crucial to the understanding of formation mechanisms of allergic diseases symptoms and development of prevention programs. However, this parameter has been studied very insufficiently in Russia.
E. M. Kamaltynova, I. A. Deev, L. M. Ogorodova, E. von Mutsius, S. Illi, M. M. Fedotova, E. A. Karbainova, D. S. Afanasyeva   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Allergen Sensitization in Patients with Skin Diseases in Shanghai, China

Journal of Asthma and Allergy, 2023
Chunjiao Zheng, Ying Zou Skin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Ying Zou, Skin and Cosmetic Research Department, Shanghai Skin ...
Zheng C, Zou Y
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Prevalence of sensitization to fungi in patients with respiratory allergy

Revista Alergia México, 2016
Background: As part of the etiology of respiratory allergy we have genetics, prenatal factors and sensitivity to various airborne allergens, between these fungi are found.
Sandra Nora González-Díaz, Alfredo Arias-Cruz, Jesús Arturo Ibarra-Chávez, Bárbara Elizondo-Villarreal, Dulce María Rivero-Arias, María del Rocío Salinas-Díaz   +5 more
doaj   +1 more source

Causal relationship between allergy and seborrheic dermatitis

Бюллетень сибирской медицины, 2022
Seborrheic dermatitis is a chronic relapsing inflammatory skin disease associated with overproduction of sebum and activation of the fungal skin microbiota characterized by the presence of erythematous pruritic patches and plaques with greasy scales in ...
A. A. Barilo, S. V. Smirnova
doaj   +1 more source