Results 41 to 50 of about 121,797 (299)

Development Status and Evaluation Strategy Considerations on In Vitro Alternative Methods for Skin Sensitization Testing of Medical Devices

Zhongguo yiliao qixie zazhi
Tests for skin sensitization are commonly used methods for evaluating the sensitization of medical devices. With the development of animal welfare and scientific technology, various toxicology evaluation tools such as in vitro experiments and non-testing
Likui SUN, Xiaoxia SUN, Xiaofei WANG, Chenghu LIU, Min WAN   +4 more
doaj   +1 more source

Is There a Need for Repetition of Skin Test in Childhood Allergic Diseases? Repetition of Skin Test and Allergic Diseases

Allergology International, 2014
Background: Skin prick tests are widely used to determine sensitivity in allergic diseases. There is limited information about the natural history of skin sensitization tests and factors that affect them.
Mahmut Dogru, Ilknur Bostanci, Serap Ozmen, Tayfur Ginis, Handan Duman   +4 more
doaj   +1 more source

Cockroach Allergy and Asthma in a 30-Year-Old Man [PDF]

, 1999
A growing body of evidence has implicated allergens derived from cockroaches as an important environmental factor that may aggravate asthma in sensitized persons. We present the case of a 30-year-old man with asthma and a cockroach allergy.
Bourdin, Joël-André, Frank, Marie-Thérèse, Mignaval, Pierre   +2 more
core   +2 more sources

The Sensitive Skin Syndrome

Indian Journal of Dermatology, 2012
Sensitive skin syndrome (SSS) is a common and challenging condition, yet little is known about its underlying pathophysiology. Patients with SSS often present with subjective complaints of severe facial irritation, burning, and/or stinging after application of cosmetic products. These complaints are out of proportion to the objective clinical findings.
Hadar Lev-Tov, Howard I Maibach
openaire   +3 more sources

Evaluation of the Skin Sensitization Potential of Carbon Nanotubes Using Alternative In Vitro and In Vivo Assays

Toxics, 2020
Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in ...
Sung-Hyun Kim, Dong Han Lee, Jin Hee Lee, Jun-Young Yang, Hyo-Sook Shin, JeongPyo Lee, Kikyung Jung, Jayoung Jeong, Jae-Ho Oh, Jong Kwon Lee   +9 more
doaj   +1 more source

Proteolytic activity accelerates the TH17/TH22 recall response to an epicutaneous protein allergen-induced TH2 response

Journal of Immunotoxicology, 2022
Epicutaneous exposure to protein allergens, such as papain, house dust mite (HDM), and ovalbumin (OVA), represents an important mode of sensitization for skin diseases including protein contact dermatitis, immunologic contact urticaria, and atopic ...
Akira Ogasawara, Takuo Yuki, Asuka Katagiri, Yi-Ting Lai, Yutaka Takahashi, David Basketter, Hitoshi Sakaguchi   +6 more
doaj   +1 more source

The clinical meaning of histamine skin reactivity [PDF]

, 2015
The definition of the “atopic state”, i.e. subjects presenting at least one skin wheal with a minimum diameter of 3 mm induced by an allergen skin-prick test (ASPT), is based on the assumption that wheal size depends entirely on the amount of histamine
BARRETO, Mario, RONCHETTI, ROBERTO
core   +1 more source

An Adverse Outcome Pathway for Sensitization of the Respiratory Tract by Low-Molecular-Weight Chemicals: Building Evidence to Support the Utility of In Vitro and In Silico Methods in a Regulatory Context [PDF]

, 2017
Sensitization of the respiratory tract is an important occupational health challenge, and understanding the mechanistic basis of this effect is necessary to support the development of toxicological tools to detect chemicals that may cause it. Here we use
3Rs Management & Consulting ApS (3RsMC ApS), Lyngby, Denmark., Cochrane, Stella, Enoch, Steven J., Ezendam, Janine, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany., National Institute for Public Health and the Environment (RIVM), Centre for Health Protection, Bilthoven, The Netherlands., Physicians Committee for Responsible Medicine, Washington, District of Columbia., Roggen, Erwin L., School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, England., Sewald, Katherina, Sullivan, Kristie M., Unilever SEAC, Sharnbrook, United Kingdom.   +11 more
core   +1 more source

SENSITIZATION SPREAD AND SKIN SENSITIVITY TO HISTAMINE IN CHILDREN OF SCHOOL AGE IN TOMSK AND TOMSK REGION

Педиатрическая фармакология, 2013
Study of sensitization spread is crucial to the understanding of formation mechanisms of allergic diseases symptoms and development of prevention programs. However, this parameter has been studied very insufficiently in Russia.
E. M. Kamaltynova, I. A. Deev, L. M. Ogorodova, E. von Mutsius, S. Illi, M. M. Fedotova, E. A. Karbainova, D. S. Afanasyeva   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source