Results 61 to 70 of about 1,109,767 (188)

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization [PDF]

, 2015
Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between ...
Andrade, Carolina H., Strickland, Judy, Tropsha, Alexander, Fourches, Denis, Alves, Vinicius M., Muratov, Eugene, Kleinstreuer, Nicole   +6 more
core   +1 more source

Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation

Journal of Immunotoxicology, 2019
FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Jonathan Dosik, Herman Ellman, Iain Stuart   +2 more
doaj   +1 more source

A Case Report of a Successful Allergen Immunotherapy with Candida Albicans in Patient with Sever Atopic Dermatitis Sensitive to Candida Albicans [PDF]

Patient Safety and Quality Improvement Journal, 2019
Introduction: Atopic dermatitis (AD) is an inflammatory, chronic, relapsing, itchy skin disease with an immunologic basis. This disease is associated with itchy skin lesions (pruritus), dry skin (xerosis) and plaques of eczema. The role of aeroallergens,
Farahzad Jabbari Azad, Payam Payandeh, Pouran Layegh, Javad Fadaee   +3 more
doaj   +1 more source

A chemical dataset for evaluation of alternative approaches to skin-sensitization testing

, 2004
Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin-sensitization potential ...
Gerberick, G. Frank, Dearman, Rebecca J., Kern, Petra S., Basketter, David A., Patlewicz, Grace Y., Ryan, Cindy A., Kimber, Ian   +6 more
core   +1 more source

Gallates – toxicological data and a pilot study on the prevalence of contact sensitization [PDF]

Pharmacia
Propyl, octy- and dodecyl gallates are largely used in food, cosmetic and pharmaceutical industry as additives – preservatives. The main source of exposure non-related with food consumption is their use of cosmetic products.
Maya G. Lyapina, Silvia P. Tsanova-Savova, Maria G. Nikolova, Maia L. Vizeva, Georgi Ts. Momekov   +4 more
doaj   +3 more sources

Sensitive skin is a neuropathic disorder [PDF]

Experimental Dermatology, 2019
AbstractSensitive skin is defined by the occurrence of unpleasant sensations such as tingling, burning, tautness, itching or pain. Mechanisms explaining sensitive skin are controversial, and many hypotheses have been proposed. Because sensitive skin is primarily characterized by a wide variety of neuropathic‐like symptoms, it is highly likely that ...
Flavien Huet, Laurent Misery
openaire   +2 more sources

Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age. [PDF]

PLoS ONE, 2012
Immune specific genes as well as genes regulating the formation of skin barrier are major determinants for eczema manifestation. There is a debate as to whether allergic sensitization and filaggrin gene (FLG) variants lead to eczema or FLG variants and ...
Ali H Ziyab, Wilfried Karmaus, Mitra Yousefi, Susan Ewart, Eric Schauberger, John W Holloway, Hongmei Zhang, Syed Hasan Arshad   +7 more
doaj   +1 more source

Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study. [PDF]

, 2013
BACKGROUND: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age.
Oviedo, G, Platts-Mills, TA, Vaca, M., Workman, L. J., Platts-Mills, T. A. E., Barreto, M. L., Rodrigues, LC, Moncayo, A-L, Workman, LJ, Vaca, M, Chico, ME, Platts-Mills, TAE, Oviedo, G., Barreto, ML, Moncayo, AL, Rodrigues, L. C., Chico, M. E., Cooper, PJ, Cooper, Philip, Moncayo, A.-L.   +19 more
core   +1 more source

In Vivo Irritation and Sensitization Assessment of Cypermethrin, Pymetrozine, and Indoxacarb–Emamectin Benzoate Combination in Test Animals

Journal of Toxicology
Insecticides are widely used to protect agricultural and plantation products from pests and plant-disrupting organisms. Prior to market distribution, pesticide-containing products must undergo safety evaluations, including assessments of potential skin ...
Wahyu Daradjat Natawigena, Kirana Fayruz Swarga, Gloria Mahayarni Lastiar Sitinjak, Muhammad Ilfadry Rifasta, Agus Susanto, Gofarana Wilar, Cecep Suhandi   +6 more
doaj   +1 more source

Decreased skin colonization with Malassezia spp. and increased skin colonization with Candida spp. in patients with severe atopic dermatitis

Frontiers in Medicine
BackgroundAtopic dermatitis (AD) is a chronic relapsing inflammatory skin disease in which patients are sensitized towards a plethora of allergens. The hosts fungal microbiota, the mycobiota, that is believed to be altered in patients suffering from AD ...
Lukas Storz, Lukas Storz, Bettina Schmid, Philipp Peter Bosshard, Philipp Peter Bosshard, Peter Schmid-Grendelmeier, Peter Schmid-Grendelmeier, Peter Schmid-Grendelmeier, Marie-Charlotte Brüggen, Marie-Charlotte Brüggen, Marie-Charlotte Brüggen, Claudia Lang, Claudia Lang   +12 more
doaj   +1 more source