Results 41 to 50 of about 15,992,675 (351)

Delabelling beta-lactam allergy

Frontiers in Pharmacology
Background: Hypersensitivity to beta-lactam (BL) antibiotics is one of the most frequent reported drug allergies. In our population, it is common to find labels of BL allergy in electronic medical records (EMRs) that have not been assessed. The objective
Gustavo-Jorge Molina-Molina, Diana Rocío Garnica Velandia, Diana Rocío Garnica Velandia, Blanca Andrés-López, Carolina Perales, Laura Marin-Asensio, Yanina Jurgens, Olga Esteso, Carolina Escobar, Xavier Vidal, Xavier Vidal, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Gómez-Ganda, Dolores Rodríguez, Eva Montané, Eva Montané, Victoria Cardona, Victoria Cardona, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fatal ampicillin-sulbactam anaphylaxis in a 34-year-old male

Journal of Allergy and Clinical Immunology: Global, 2023
A 34-year-old man receiving his first dose of ampicillin-sulbactam for osteomyelitis in a hospital setting experienced fatal drug-induced anaphylaxis.
Marielle C. Young, MD, MPH, Chantal Lemoine, MD, John J.O. Accarino, MD, Sandra B. Nelson, MD, Jerome C. Crowley, MD, MPH, Kimberly G. Blumenthal, MD, MSc   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Frequência de lesões macroscópicas em carcaças de bovinos reagentes ao teste tuberculínico

Arquivos do Instituto Biológico
O objetivo deste trabalho foi analisar a frequência de lesões macroscópicas sugestivas de tuberculose em carcaças de bovinos reagentes ao teste intradérmico de tuberculose.
Mariana Assunção de Souza, Nadia Grandi Bombonato, Pollyanna Mafra Soares, Gabriela Bim Ramos, Mariane Pacheco dos Santos, Muriell Ribeiro Ganda, Anna Monteiro Correia Lima-Ribeiro   +6 more
doaj   +1 more source

Purification and characterization of M-177, a 177 kDa allergen, from the house dust mite Dermatophagoides farinae

Allergology International, 1999
A high molecular weight allergen, M-177, was recently discovered in the house dust mite, Dermatophagoides farinae (D. farinae). The aims of this study were to develop a conventional purification procedure for M-177 and then to analyze some of the ...
Akihiro Fujikawa, Seiji Kawamoto, Hideki Hokazono, Tsunehiro Aki, Seiko Shigeta, Osamu Suzuki, Takeshi Wada, Toshihiko Jyo, Kazuhisa Ono   +8 more
doaj   +1 more source

Measurement and interpretation of skin prick test results

Clinical and Translational Allergy, 2016
BackgroundThere are several methods to read skin prick test results in type-I allergy testing. A commonly used method is to characterize the wheal size by its ‘average diameter’.
J. V. D. van der Valk, R. Gerth van Wijk, E. Hoorn, L. Groenendijk, I. Groenendijk, N. D. de Jong   +5 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Improved Skin Test for Differential Diagnosis of Bovine Tuberculosis by the Addition of Rv3020c-Derived Peptides

Clinical and Vaccine Immunology, 2012
A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a “DIVA”
G. Jones, A. Whelan, D. Clifford, M. Coad, H. Vordermeier   +4 more
semanticscholar   +1 more source

The Development of a Skin Cancer Classification System for Pigmented Skin Lesions Using Deep Learning

Biomolecules, 2020
Recent studies have demonstrated the usefulness of convolutional neural networks (CNNs) to classify images of melanoma, with accuracies comparable to those achieved by dermatologists. However, the performance of a CNN trained with only clinical images of
S. Jinnai, N. Yamazaki, Y. Hirano, Yohei Sugawara, Y. Ohe, Ryuji Hamamoto   +5 more
semanticscholar   +1 more source