Results 51 to 60 of about 8,447,095 (299)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Delabelling beta-lactam allergy

Frontiers in Pharmacology
Background: Hypersensitivity to beta-lactam (BL) antibiotics is one of the most frequent reported drug allergies. In our population, it is common to find labels of BL allergy in electronic medical records (EMRs) that have not been assessed. The objective
Gustavo-Jorge Molina-Molina, Diana Rocío Garnica Velandia, Diana Rocío Garnica Velandia, Blanca Andrés-López, Carolina Perales, Laura Marin-Asensio, Yanina Jurgens, Olga Esteso, Carolina Escobar, Xavier Vidal, Xavier Vidal, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Gómez-Ganda, Dolores Rodríguez, Eva Montané, Eva Montané, Victoria Cardona, Victoria Cardona, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Accuracy of an artificial intelligence as a medical device as part of a UK-based skin cancer teledermatology service

Frontiers in Medicine
IntroductionAn artificial intelligence as a medical device (AIaMD), built on convolutional neural networks, has demonstrated high sensitivity for melanoma. To be of clinical value, it needs to safely reduce referral rates.
Helen Marsden, Polychronis Kemos, Marcello Venzi, Mariana Noy, Shameera Maheswaran, Nicholas Francis, Christopher Hyde, Daniel Mullarkey, Dilraj Kalsi, Lucy Thomas   +9 more
doaj   +1 more source

Item - Test Alternate Title

Item - Test Description ...
Item - Test Creator 1, Item - Test Creator 3, Item - Test Creator 2   +2 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Las pruebas epicutáneas de contacto en medicina laboral Patch testing in occupational medicine

Medicina y Seguridad del Trabajo, 2013
Dentro de la Medicina Laboral las dermatosis ocupacionales suponen entre el 30-60% del total de enfermedades profesionales y, dentro de ellas el 80-90% son dermatitis de contacto.
Carolina Granados Rincón, Nelly Machado Benavides, Ana Rita Rodrigues-Barata, Luis Conde-Salazar Gómez   +3 more
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Skin Test for Cutaneous Adverse Drug Reactions

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2020
Background: The incidence of drug eruptions is increasing during the last few years due to a large number of new medications. Early detection of the causative agent and the prevention from exposure are crucial managements in terms of drug eruption ...
Yusuf Wibisono, Damayanti Damayanti
doaj   +1 more source