Results 91 to 100 of about 341,517 (311)

Engineered biopolymeric scaffolds for chronic wound healing

Frontiers in Physiology, 2016
Skin regeneration requires the coordinated integration of concomitant biological and molecular events in the extracellular wound environment during overlapping phases of inflammation, proliferation, and matrix remodeling. This process is highly efficient
Laura E Dickinson, Sharon Gerecht
doaj   +1 more source

YAP and TAZ Regulate Skin Wound Healing [PDF]

Journal of Investigative Dermatology, 2014
The Hippo signaling pathway regulates organ size, tissue regeneration, and stem cell self-renewal. The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological functions of the Hippo pathway.
Lee, MJ, Byun, MR, Furutani-Seiki, M, Hong, JH, Jung, HS   +4 more
openaire   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Use of Cocoa Ethanolic Extract for Treatment of Staphylococcal Infection in Rabbit-skin Model [PDF]

, 2016
In septic condition, the skin normal flora Staphylococcal spp. may trigger local and sistemic skin infection. In this study antibacterial activity of cocoa ethanolic extract (CEE) against Staphylococcus aureus and ...
Jati, M. (Misnawi), Mufida, D. C. (Diana), Perwitahati, D. (Desyana), Syamsuddin, I. K. (Ihda), Tamarizki, M. (Mekania), Tunjung-Sari, A. B. (Ariza), Wahyudi, T. (Teguh)   +6 more
core  

Anti-inflammatory and wound healing properties of Malaysia tualang honey [PDF]

, 2016
Inflammation is a biological response and a defence mechanism by the body to remove harmful stimuli followed by the healing process. Healing is a process of skin and other soft tissue repair at the site of injury. However, uncontrolled inflammation could
Devasvaran, Kogilavanee, Yong, Yoke Keong   +1 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Preoperative Skin Conditioning: Extracellular Matrix Clearance and Skin Bed Preparation, A New Paradigm. [PDF]

, 2019
This paper introduces the concept of "skin bed preparation" prior to surgical procedures. Following the theory of chronic wound bed preparation and adapting the skin model to one of chronic wound changes related to extrinsic and intrinsic factors, a ...
Cohen, Steven R, Fagien, Steven, Widgerow, Alan D   +2 more
core  

Regenerative Scar-Free Skin Wound Healing

Tissue Engineering Part B: Reviews, 2019
Millions of people every year develop scars in response to skin injuries after surgery, trauma, or burns with significant undesired physical and psychological effects. This review provides an update on engineering strategies for scar-free wound healing and discusses the role of different cell types, growth factors, cytokines, and extracellular ...
Mehri, Monavarian, Safaa, Kader, Seyedsina, Moeinzadeh, Esmaiel, Jabbari   +3 more
openaire   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

First experience with a new negative pressure incision management system on surgical incisions after cardiac surgery in high risk patients [PDF]

, 2011
BACKGROUND: Sternal wound infection remains a serious potential complication after cardiac surgery. A recent development for preventing wound complications after surgery is the adjunctive treatment of closed incisions with negative pressure wound ...
COLLI, ANDREA
core   +2 more sources