Results 61 to 70 of about 8,072 (166)
Role of the minimal regions of the SLC19A2 and SLC19A3 promoters in mediating the NNK effect.
, 2013 Full-length and minimal SLC19A2 (A) and SLC19A3 (B) promoters in pGL3-Basic were transiently transfected in 266-6 pancreatic acinar cells; luciferase assays were performed as described under “Materials and Methods”.
Veedamali S. Subramanian (452244) +2 more
core +1 more source
Transcriptomic Insights Into the Immune Repertoire of an Antarctic Sponge
Ecology and Evolution, Volume 15, Issue 12, December 2025.Antarctic marine sponges are essential components of the benthic fauna, playing a crucial role in structuring this ecosystem through their own biological activities and their symbiotic relationships with diverse microorganisms. Yet, the transcriptional repertoire and the immune responses associated with interactions with microorganisms in this unique ...
Leslie K. Daille +3 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
, 2020 As life expectancy increases, the prevalence of osteoporosis is increasing. In addition to vitamin D which is well established to have an association with osteoporosis, B vitamins, such as thiamine, folate (vitamin B9), and cobalamin (vitamin B12), could
In-Bo Han +8 more
core +1 more source
Medical Journal of Australia, Volume 223, Issue 9, Page 484-491, November 2025.Abstract Introduction Monogenic diabetes accounts for 2–5% of diabetes. Although its identification has substantial therapeutic implications, more than 80% of affected individuals are undiagnosed or misdiagnosed as having type 1 or 2 diabetes. This consensus statement reviews genetic testing for monogenic diabetes in adults and provides evidence‐based ...
Sunita MC De Sousa +10 more
wiley +1 more source
Structure‐based discovery of thiamine uptake inhibitors
British Journal of Pharmacology, Volume 182, Issue 22, Page 5611-5626, November 2025.Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel +2 more
wiley +1 more source
Journal of Clinical Research in Pediatric Endocrinology, 2013 Thiamine-responsive megaloblastic anemia (TRMA) is a clinical triad characterized by megaloblastic anemia, non-autoimmune diabetes mellitus, and sensory-neural hearing loss. Mutations in the thiamine transporter gene, solute carrier family 19, member 2 (SLC19A2), have been associated with TRMA.
Ghaemi, Nosrat +4 more
openaire +2 more sources
Deletion of SLC19A2, the High Affinity Thiamine Transporter, Causes Selective Inner Hair Cell Loss and an Auditory Neuropathy Phenotype [PDF]
Journal of the Association for Research in Otolaryngology, 2006 Mutations in the gene coding for the high-affinity thiamine transporter Slc19a2 underlie the clinical syndrome known as thiamine-responsive megaloblastic anemia (TRMA) characterized by anemia, diabetes, and sensorineural hearing loss. To create a mouse model of this disease, a mutant line was created with targeted disruption of the gene.
M C, Liberman +3 more
openaire +2 more sources
Food Biomacromolecules, Volume 2, Issue 3, Page 271-287, September 2025.The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar +5 more
wiley +1 more source
A novel mutation in the SLC19A2 gene in a Tunisian family with thiamine‐responsive megaloblastic anaemia, diabetes and deafness syndrome [PDF]
British Journal of Haematology, 2001 Thiamine‐responsive megaloblastic anaemia (TRMA) syndrome with diabetes and deafness was found in two patients from a Tunisian kindred. The proband was homozygous for a novel mutation, 287delG, in the high‐affinity thiamine transporter gene, SLC19A2. We demonstrated that fibroblasts from this patient exhibited defective thiamine transport.
S, Gritli +11 more
openaire +2 more sources