Results 81 to 90 of about 8,072 (166)

Ectoin attenuates cortisone‐induced skin issues by suppression GR signaling and the UVB‐induced overexpression of 11β‐HSD1

Journal of Cosmetic Dermatology, Volume 23, Issue 12, Page 4303-4314, December 2024.
Abstract Background Accelerated pace of modern work and lifestyles subject individuals to various external and psychological stressors, which, in turn, can trigger additional stress through visible signs of fatigue, hair loss, and obesity. As the primary stress hormone affecting skin health, cortisol connects to the glucocorticoid receptor (GR) to ...
Dailin Xu, Yue Wu
wiley   +1 more source

Treatment of genetic defects of thiamine transport and metabolism

, 2016
Introduction: Thiamine is a key cofactor for energy metabolism in brain tissue. There are four major genetic defects (SLC19A2, SLC19A3, SLC25A19 and TPK1) involved in the metabolism and transport of thiamine through cellular and mitochondrial membranes ...
Juan Darío Ortigoza-Escobar (2802793), Angela Arias (2802790), Belén Pérez-Dueñas (2802784), Marta Molero-Luis (499096), Laura Martí-Sánchez (2802796), Pilar Rodriguez-Pombo (2802787), Rafael Artuch (435125)   +6 more
core   +1 more source

Validation of gene expression.

, 2019
Dose-dependent effects of gamma and proton radiation on Aen, Cdkn1a, Ephx1 and Slc19a2 expression in aorta, kidney, lung and heart. Gene expression was measured by quantitative RT-PCR.
Jenine K. Sanzari (306909), Ann R. Kennedy (306913), Dimitra Sarantopoulou (6320906), Emanuela Ricciotti (2020690), Tilo Grosser (265007), Amber J. Kiliti (6320912), Gregory R. Grant (4109659), Gabriel S. Krigsfeld (6320909)   +7 more
core   +1 more source

Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia

Communications Biology
The Central Plains Han Chinese (CPHC) is the typical agricultural population of East Asia. Investigating the genome of the CPHC is crucial to understanding the genetic structure and adaptation of the modern humans in East Asia.
Xiaoyang Qiao, Jianxiang Shi, Hongen Xu, Kai Liu, Youwei Pu, Xia Xue, Wangshan Zheng, Yongbo Guo, Hao Ma, Chuan-Chao Wang, Habtom K. Bitsue, Xiaoyu Xu, Shanshan Wang, Jingru Zhao, Xiangqian Guo, Xinyue Hou, Xinwei Wang, Lei Peng, Zan Qiu, Bing Su, Wenxue Tang, Yaoxi He, Jiancheng Guo, Zhaohui Yang   +23 more
doaj   +1 more source

Recurrent Stroke in a Child with TRMA Syndrome and SLC19A2 Gene Mutation.

Iranian journal of child neurology
Here we report a 5-month-old boy with thiamine Responsive Megaloblastic Anemia syndrome (TRMA syndrome) with several attacks of stroke, admitted to Mofid Children's Hospital, Tehran, Iran, in 2016. In addition to the cardinal clinical manifestations of the syndrome, other manifestations comprise thiamine-responsive megaloblastic anemia, diabetes ...
Parvaneh, Karimzadeh, Toktam, Moosavian, Hamidreza, Moosavian   +2 more
openaire   +1 more source

Structural basis of thiamine transport and drug recognition by SLC19A3

Nature Communications
Thiamine (vitamin B1) functions as an essential coenzyme in cells. Humans and other mammals cannot synthesise this vitamin de novo and thus have to take it up from their diet.
Florian Gabriel, Lea Spriestersbach, Antonia Fuhrmann, Katharina E. J. Jungnickel, Siavash Mostafavi, Els Pardon, Jan Steyaert, Christian Löw   +7 more
doaj   +1 more source

Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells

, 2002
The liver is an important site for thiamin metabolism, utilization, and storage. Little is known about the mechanism of thiamin uptake by the human liver. In this study, we examined cellular and molecular aspects of the human liver thiamin uptake process
Said, Hamid M, Reidling, Jack C, Ortiz, Alvaro   +2 more
core   +1 more source

Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome

Frontiers in Neuroscience
BackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs.
Uppala Radhakrishna, Uppala Radhakrishna, Rupa Radhakrishnan, Lavanya V. Uppala, Srinivas B. Muvvala, Jignesh Prajapati, Rakesh M. Rawal, Ray O. Bahado-Singh, Senthilkumar Sadhasivam   +8 more
doaj   +1 more source

Dietary thiamine enhances thiamine transport, carbohydrate absorption, glycolysis, and antioxidant properties in Macrobrachium nipponense when fed a high-carbohydrate diet

Aquaculture Reports
Thiamine serves as a cofactor of key enzymes involved in glucose metabolism, and its regulatory role in high-carbohydrate diet has not been reported in crustaceans.
Yonghui Jian, Jiaxin Song, Zhiyuan Chen, Dongsheng Zhou, Youqin Kong, Yujie Liu, Yixiang Zhang, Hongfeng Bai, Zhili Ding   +8 more
doaj   +1 more source

Thiamine status and genes encoding intestinal thiamine transporters and transcription factors in obese subjects

Background and aims: The inconsistent data on thiamine status in obese subjects necessitates an examination of genes associated with intestinal absorption of thiamine.
Dogan, Serkan, Dizdar, Oguzhan Sıtkı, Genton, Laurence, GÜNDOĞAN, KÜRŞAT, Erdem, Serife, CANATAN, HALİT, EKEN, AHMET, Deliktas, Elif Dilek, Genton Graf, Laurence   +8 more
core   +1 more source