Results 141 to 150 of about 1,479 (176)

Chronic Enteropathy Associated with <i>Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1)</i> with Positive Immunohistochemistry for SLCO2A1 Protein

Internal Medicine, 2022
Chronic enteropathy associated with solute carrier organic anion transporter family, member 2A1 (SLCO2A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by chronic persistent anemia and hypoproteinemia. Its diagnosis typically requires a genetic analysis.
Takanori Kanai, Naoki Hosoe, Anna Tojo   +2 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

Four Variants of SLCO2A1 Identified in Three Chinese Patients with Chronic Enteropathy Associated with the SLCO2A1 Gene

Digestive Diseases and Sciences, 2020
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is an enteropathy characterized by multiple small intestinal ulcers of nonspecific histology, also known as chronic nonspecific multiple ulcers of the small intestine. The SLCO2A1 gene encodes a prostaglandin transporter (PGT).The aim of this study was to investigate the clinical ...
Yongjun Wang, Xiaowei Liu, Xiaoliu Shi   +2 more
exaly   +3 more sources

Functional analysis of mutant SLCO2A1 transporters found in patients with chronic enteropathy associated with SLCO2A1

Journal of Gastroenterology and Hepatology, 2022
AbstractBackground and AimChronic enteropathy associated with the solute carrier organic anion transporter family member 2A1 (SLCO2A1), or CEAS, causes anemia and hypoalbuminemia in young people. Dysfunction of the SLCO2A1 transporter protein is thought to involve genetic mutation, but mutant proteins have not been functionally characterized.
Satowa Seki, Gen Tanaka, Toru Kimura, Mari Hayashida, Jun Miyoshi, Minoru Matsuura, Hiroyuki Sakurai, Tadakazu Hisamatsu   +7 more
openaire   +2 more sources

Homozygous Missense Variant in the Solute Carrier Organic Anion Transporter 2A1 (SLCO2A1) Gene Underlies Isolated Nail Clubbing

Genes, 2023
Background: Inherited isolated nail clubbing is a very rare Mendelian condition in humans, characterized by enlargement of the terminal segments of fingers and toes with thickened nails.
Muhammad Umair, Khadim Shāh, Farooq Ahmad   +2 more
exaly   +2 more sources

Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1

Drug Metabolism and Pharmacokinetics, 2022
The prostaglandin (PG) transporter SLCO2A1 regulates PGE2 signaling and interacts with many drugs, and SLCO2A1 defects is associated with PG metabolic disorders. This study aimed to characterize a non-metabolic phenolsulfonphthalein (PSP) transport mediated by SLCO2A1.
Kazuki Yoshida, Takeo Nakanishi, Yoshinobu Nakamura   +2 more
exaly   +3 more sources

Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10

American Journal of Physiology - Cell Physiology
A previous study indicated that the ANXA2/S100A10 complex represents the regulatory component of SLCO2A1-mediated Maxi-Cl channel activity. The present study showed that apparent PGE2 uptake by C127 cells was osmoinsensitive and uncompetitively inhibited by loss of ANXA2 expression, demonstrating that ANXA2 is a regulatory factor of SLCO2A1-mediated ...
Toshiaki Okada, Takeo Nakanishi, Isao Matsuoka   +2 more
exaly   +3 more sources

P868 Clinical features of chronic enteropathy associated with SLCO2A1 gene

Journal of Crohn's and Colitis, 2023
Abstract Background Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations of the SLCO2A1 gene which encodes a prostaglandin transporter. This disease is rare and intractable characterized by persistent blood and protein loss. There are few reports from
J Umeno, Y Fuyuno, T Torisu, Y Matsuno, M Esaki, S Yanai, N Ohmiya, T Hisamatsu, K Watanabe, N Hosoe, H Ogata, F Hirai, T Hisabe, T Matsui, T Kitazono, T Matsumoto   +15 more
openaire   +1 more source

SLCO2A1 Gene Variant in a Portuguese Patient with Primary Hypertrophic Osteoarthropathy

2022
Primary hypertrophic osteoarthropathy is a rare disease characterized by three major clinical symptoms: pachydermia,periostosis, and digital clubbing. Diagnosis of primary hypertrophic osteoarthropathy is based on clinical and radiographiccharacteristics confirmed by genetic studies.
Cardoso, Ivana, Português, Português, Português, Português   +4 more
openaire   +3 more sources

Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1

Journal of Pharmaceutical Sciences, 2017
To understand interaction of drugs with the prostaglandin transporter OATP2A1/SLCO2A1 that regulates disposition of prostaglandins, we explored the impact of 636 drugs in an FDA-approved drug library on 6-carboxyfluorescein (6-CF) uptake by OATP2A1-expressing HEK293 cells (HEK/2A1).
Shunsuke, Kamo, Takeo, Nakanishi, Rika, Aotani, Yoshinobu, Nakamura, Tomoka, Gose, Ikumi, Tamai   +5 more
openaire   +2 more sources