Results 81 to 90 of about 907,577 (363)

The effect of sleep deprivation on cortical excitability : a neuromagnetic approach [PDF]

, 2017
Despite decades of study, no ironclad conclusion has been reached concerning the biological function of sleep in humans. Recent theories have proposed that sleep might play a role in maintaining cortical excitability at safe levels by downregulating ...
Rekola, Lauri
core  

Altered sleep homeostasis in rev-erbα knockout mice [PDF]

, 2016
Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes.
Albrecht, Urs, Chappuis, Sylvie, Emmenegger, Yann, Franken, Paul, La Spada, Francesco, Mang, Géraldine M., Ripperger, Jürgen A.   +6 more
core   +1 more source

Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation

British Journal of Pharmacology, 2019
Sleep deprivation compromises learning and memory in both humans and animals, and can be reversed by administration of modafinil, a drug promoting wakefulness.
Yin Cao, Qinglin Li, Lulu Liu, Hui Wu, Fei Huang, Changhong Wang, Yunyi Lan, F. Zheng, Faping Xing, Qiang Zhou, Qi Li, Hailian Shi, Beibei Zhang, Zheng-tao Wang, Xiaojun Wu   +14 more
semanticscholar   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation [PDF]

, 2010
Martins PJ, Marques MS, Tufik S, D'Almeida V. Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation. Am J Physiol Endocrinol Metab 298: E726-E734, 2010.
D'Almeida, Vania, Forcina Martins, Paulo Jose, Marques, Marina Soares, Tufik, Sergio   +3 more
core   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Sleep deprivation detected by voice analysis.

PLoS Computational Biology
Sleep deprivation has an ever-increasing impact on individuals and societies. Yet, to date, there is no quick and objective test for sleep deprivation. Here, we used automated acoustic analyses of the voice to detect sleep deprivation.
Etienne Thoret, Thomas Andrillon, Caroline Gauriau, Damien Léger, Daniel Pressnitzer   +4 more
doaj   +1 more source

The impact of sleep deprivation on the brain

Acta Clinica Croatica, 2016
Each sleep phase is characterized by specific chemical, cellular and anatomic events of vital importance for normal neural functioning. Different forms of sleep deprivation may lead to a decline of cognitive functions in individuals.
Tatjana Trošt Bobić, Ana Šečić, Iris Zavoreo, Valentina Matijević, Branimir Filipović, Željka Kolak, Vanja Bašić Kes, Dubravka Ciliga, Dubravka Sajković   +8 more
doaj   +1 more source

Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

PLoS ONE, 2019
Chronic pain patients often suffer from insomnia or impaired sleep which has been associated with increased pain sensitivity, but a limited amount of studies have investigated the effects of total sleep deprivation on central pain mechanisms.
A. Staffe, Mathias Winther Bech, Sara Louise Kjær Clemmensen, H. S. Nielsen, D. B. Larsen, K. Petersen   +5 more
semanticscholar   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source