Results 101 to 110 of about 62,872 (285)

Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]

, 2009
This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Melatonin deficiency and sleep fragmentation in frequent travelers: A modern circadian health crisis

Journal of Education, Health and Sport
Background: Frequent travel disrupts the circadian rhythm, often leading to disturbed melatonin production. This disruption contributes to sleep fragmentation, reduces sleep quality, and cumulative fatigue that many travelers experience as more than ...
Aleksandra Mierniczek, Michalina Chodór, Maciej Kokoszka, Aleksandra Tomaszewska, Kinga Karczewska, Aleksandra Ćwirko-Godycka, Nikola Murawska, Natalia Dymel, Ryszard Feret, Sonia Mojzyk   +9 more
doaj   +1 more source

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, EarlyView.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

Voluntary exercise can strengthen the circadian system in aged mice [PDF]

, 2013
Consistent daily rhythms are important to healthy aging according to studies linking disrupted circadian rhythms with negative health impacts. We studied the effects of age and exercise on baseline circadian rhythms and on the circadian system's ability ...
A Davidson, A Power, A Watanabe, AA Kondratova, AC King, AJ Davidson, AJ Davidson, B Rusak, C Castillo, CJ Guenthner, DE Kolker, DF Swaab, DJ Buysse, DJ Dijk, DJ Foley, DJ Foley, E Satinoff, E. Zimmerman, EK Baehr, F Aujard, G. S. Lall, GJ Tranah, GS Passos, H Albus, H Li, H. Queenan, HT vanderLeest, I. Song, IN Karatsoreos, J Schaap, K Cho, KJ Reid, M Asai, M Harrington, M Münch, M Nagano, M Palomba, M. E. Harrington, MA Grandner, MJ Duncan, MJ Duncan, MU Gillette, MW Greene, MW Marlatt, N Mrosovsky, O Castanon-Cervantes, P. C. Molyneux, PC Yannielli, RD Nebes, S Ancoli-Israel, S Benloucif, S Farajnia, S Kiessling, S Yamazaki, S Yamazaki, S Yamazaki, S. M. Biello, SH Yoo, SJ Aton, SM Biello, T Deboer, T Yoshikawa, T. L. Leise, TA Bedrosian, TA Martino, TA Martino, TJ Nakamura, TL Leise, U Abraham, U Albrecht, VS Valentinuzzi, W Nakamura, Y Tahara, Y Zhang, Y Zhang   +74 more
core   +2 more sources

Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal [PDF]

, 2006
Every physiological function in the human body exhibits some form of circadian rhythmicity. Under pathological conditions, however, circadian rhythmicity may be dusrupted.
Ding, Jian M., Jiang, Zhou, Liu, Yanyou, Wan, Chaomin, Wang, Xiaojia, Wang, Yueqi, Wang, Yuhui, Wang, Zhengrong, Xin, Haoyang, Zheng, Hang   +9 more
core   +3 more sources

Investigation of the skin recovery dynamics following acute sleep deprivation and the correlations among biological parameters

Sleep Research, EarlyView.
Abstract Background Sleep deprivation leads to changes in circadian rhythm, causing skin problems and aging. Whether acute sleep deprivation can be normalized after 14 days of natural skin metabolism is an important indicator for guiding treatment of sleep‐related skin physiological changes and mechanisms.
Qianxin Zhu, Yuanyuan Diao, Yi Huang, Liang Chen, Vasilisa Trotsenko, Hui Du, Jianping Pang, Naining Song   +7 more
wiley   +1 more source

Seasonal variation in the incidence of central serous chorioretinopathy: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Central serous chorioretinopathy (CSC) is a chorioretinal disease characterised by serous subretinal fluid (SRF) in the macula, resulting in sudden central vision loss. It predominantly affects working‐age adults, particularly men aged 30 to 60 years.
I. Made Ferdiko Hutamadella, Emil Ørnberg, Mark P. Breazzano, Lasse Jørgensen Cehofski, Chui Ming Gemmy Cheung, Kristina Pfau, M. Cem Sabaner, Lorenzo Ferro Desideri, Camiel J. F. Boon, Yousif Subhi, Elon H. C. van Dijk   +10 more
wiley   +1 more source

Сontribution of circadian rhythms to the development of neurological disorders after prolonged anesthesia [PDF]

Клиническая практика
Despite the improvement of pre-, intra- and postoperative care methods, the problem of the development of postoperative neurological complications following prolonged anesthesia remains.
Nikita A. Mazurov, Oksana A. Kicherova, Tatyana E. Verbakh, Lyudmila I. Reichert, Yulia I. Doyan, Valentina A. Saltanova   +5 more
doaj   +1 more source

Improving access to help with poor sleep across youth mental health services: Interim implementation and clinical outcomes

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives There is a high, unmet sleep need in young people with mental health difficulties. We took a whole‐system approach to improving access to sleep support across a youth mental health system (14–25 years). Methods We used the Exploration, Preparation, Implementation and Sustainment (EPIS) framework to develop an implementation ...
Rebecca Rollinson, Ben Ewing, Sarah Reeve, Adam Graham, Jonathan Lyons, Brioney Gee, Jonathon Wilson, Ioana Tofan, Kelly Semper, Tim Clarke   +9 more
wiley   +1 more source