Results 251 to 260 of about 21,177 (293)

Sleeping sickness and the brain

Cellular and Molecular Life Sciences, 2002
Recent progress in understanding the neuropathological mechanisms of sleeping sickness reveals a complex relationship between the trypanosome parasite that causes this disease and the host nervous system. The pathology of late-stage sleeping sickness, in which the central nervous system is involved, is complicated and is associated with disturbances in
B, Enanga, R J S, Burchmore, M L, Stewart, M P, Barrett   +3 more
openaire   +3 more sources

The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda

Lancet, The, 2001
BACKGROUND: Sleeping sickness, caused by two trypanosome subspecies, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, is a parasitic disease transmitted by the tsetse fly in sub-Saharan Africa.
Eric M Fevre, Paul G Coleman, M Odiit
exaly   +2 more sources

Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene

Lancet, The, 2001
BACKGROUND: The expansion of sleeping sickness caused by Trypanosoma brucei rhodesiense beyond its traditional focus in southeast Uganda has been linked with large-scale livestock restocking.
K Picozzi, Eric M Fevre, Paul G Coleman
exaly   +2 more sources

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Sleeping Sickness

2009
Sleeping sickness or African trypanosomiasis is caused by the extracellular parasite. Trypanosoma brucei and is lethal if untreated. The encephalitic stage is characterized by disrupted sleep pattern, with sleep episodes during the day and wakefulness during the night.
Kristensson K., BENTIVOGLIO FALES, Marina   +1 more
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The pathogenesis of sleeping sickness

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980
Although the clinical and pathological features of sleeping sickness have been well recognized since the beginning of the century, we still have very little idea about how these changes are brought about. A convincing role for a trypanosome-derived toxin has yet to be established and it is probable that most tissue damage results from an ...
B M, Greenwood, H C, Whittle
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Neurobiology of sleeping sickness

Parasitology Today, 1989
The advanced stages of sleeping sickness are correlated with a spread of trypanosomes into the central nervous system (CNS), producing a disseminated encephalitis. Inflammatory reactions extend along the blood vessels causing perivascular cuffing, which consists of in filtrations and proliferations of lymphocytes and also increased numbers of ...
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The duality of sleeping sickness: focusing on sleep

Sleep Medicine Reviews, 2001
Sleeping sickness, once under control, is a re-emergent endemic parasitic disease in intertropical Africa. Its originality resides in its duality. Two trypanosome groups (Trypanososma brucei gambiense vs.rhodesiense ) are transmitted to humans by tsetse flies from two geographical areas (Western and Central Africa humid forest vs.
A, Buguet, L, Bourdon, B, Bouteille, R, Cespuglio, P, Vincendeau, M W., Radomski, M, Dumas   +6 more
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Sleeping sickness: Sleep study of a case

Electroencephalography and Clinical Neurophysiology, 1970
Abstract A 66-year-old patient with sleeping sickness was examined polygraphically 9 times in 4 months. The first clinical symptoms of the disease had been observed 4 years previously. Throughout the study period wakefulness and rapid eye movement sleep (REMS) were always normal while slow wave sleep (SWS) and intermediate sleep (Int. S) were always
B A, Schwartz, C, Escande
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Sleeping Sickness in the ‘Omics Era

PROTEOMICS – Clinical Applications, 2018
AbstractSleeping sickness is a neglected tropical disease caused by Trypanosoma brucei parasites, affecting the poorest communities in sub‐Saharan Africa. The great efforts done by the scientific community, local governments, and non‐governmental organizations (NGOs) via active patients’ screening, vector control, and introduction of improved treatment
Tiberti, Natalia, Sanchez, Jean-Charles
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Sleeping off sickness

Nature Reviews Immunology, 2019
A new study in Science identifies nemuri (nur) as encoding a secreted factor in Drosophila that has both antimicrobial and sleep-inducing properties, thus providing a direct link between sleep homeostasis and the response to infection.
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