Results 71 to 80 of about 140,774 (244)

Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan [PDF]

, 2012
BACKGROUND: Active case detection through mass community screening is a major control strategy against human African trypanosomiasis (HAT, sleeping sickness) caused by T. brucei gambiense.
Haydon Daniel T, Chappuis, F., Cox, A.P., Cox Andrew P, Checchi Francesco, Haydon, D.T., Priotto Gerardo, Priotto, Gerardo, Checchi, Francesco, Chandramohan, Daniel, Priotto, G., Haydon, Daniel T, Cox, Andrew P, Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +17 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis [PDF]

, 2010
BackgroundThe persistent spread of Rhodesian human African trypanosomiasis (HAT) in Uganda in recent years has increased concerns of a potential overlap with the Gambian form of the disease.
Fevre, Eric M., Welburn Susan C., Peter M Atkinson, Kakembo, A.S., Peter W Gething, Kakembo, Abbas S. L., Susan C Welburn, Wardrop, Nicola A., Peter W. Gething, Picozzi, K., Picozzi, K, Atkinson Peter M., Nicola A. Wardrop, Gething, Peter W., Peter M. Atkinson, Susan C. Welburn, Fèvre Eric M., Picozzi, Kim, Kakembo, Abbas S.L., Kakembo, AS, Wardrop, N.A., Eric M. Fèvre, Gething, PW, Gething, P.W., Eric M Fèvre, Fèvre, EM, Kakembo, ASL, Wardrop Nicola A., Kakembo Abbas S. L., Wardrop, NA, Abbas S L Kakembo, Nicola A Wardrop, Welburn, SC, Atkinson, PM, Kim Picozzi, Picozzi Kim, Atkinson, Peter M., Welburn, Susan C., Atkinson, P.M., Abbas S. L. Kakembo, Gething Peter W.   +40 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Challenges towards the elimination of Human African Trypanosomiasis in the sleeping sickness focus of Campo in southern Cameroon

Parasites & Vectors, 2014
The sleeping sickness focus of Campo lies along the Atlantic coast and extends along the Ntem River, which constitutes the Cameroonian and Equatorial Guinean border.
Gustave Simo, Jean Arthur Mbida Mbida, Vincent Ebo’o Eyenga, Tazoacha Asonganyi, Flobert Njiokou, Pascal Grébaut   +5 more
doaj   +1 more source

Closing in on a new treatment for sleeping sickness

eLife, 2013
A chemoproteomics approach has been employed to identify a kinase that could be used as a druggable target in efforts to develop new treatments for African sleeping sickness.
Emily R Derbyshire, Jon Clardy
doaj   +1 more source

Developing eradication investment cases for onchocerciasis, lymphatic filariasis, and human African trypanosomiasis : rationale and main challenges [PDF]

, 2013
An EIC is essentially an economic composite assessment in the broader meaning of economics, addressing thus all three fundamental economics questions. An EIC in fact answers: 1) the ‘‘What’’ question, that compares remaining in control mode versus moving
Steinmann, Peter, Marcel Tanner, Peter Steinmann, de Savigny, Don, Tediosi, Fabrizio, Fabrizio Tediosi, Don de Savigny, María Gloria Basáñez, Tanner, Marcel   +8 more
core   +2 more sources

Return‐To‐Work and Working Status After Surgery for Gastric and Esophageal Cancer: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter prospective study of 158 working‐age patients undergoing curative‐intent surgery for gastric or esophageal cancer, 78.5% were working at 18 months. Postoperative appetite loss, financial difficulties, and ≥ 10% weight loss at 6 months were associated with non‐working status.
Kentaro Goto, Shigeo Hisamori, Kohei Ueno, Hiroyasu Abe, Ryosuke Okamura, Hisahiro Hosogi, Yoshito Yamashita, Dai Manaka, Hiroaki Hata, Tatsuto Nishigori, Sanae Nakajima, Michihiro Yamamoto, Koichi Kinoshita, Shintaro Okumura, Masazumi Sakaguchi, Shigeru Tsunoda, Yu Sakagami, Koya Hida, Kazutaka Obama   +18 more
wiley   +1 more source

Border harm and affective injustice: The politics of anger at the Melilla border, Spain

American Journal of Community Psychology, EarlyView.
Abstract This article examines protests in a detention center in Melilla, Spain—a site where structural violence intersects with the everyday harms of confinement. Adopting a justice and dignity‐centered perspective, we analyze grassroots forms of resistance emerging at the border. The study focuses on the protests of Tunisian migrants and explores the
Corina Tulbure
wiley   +1 more source

Do trypanosome turncoats wait before they commit?

eLife, 2014
The strategy that sleeping sickness parasites use to evade the mammalian immune system may be linked to the metamorphosis that allows them to transfer from mammals into tsetse flies.
Cher-Pheng Ooi, Gloria Rudenko
doaj   +1 more source