Results 51 to 60 of about 21,177 (293)

Screening of Trypanosoma brucei gambiense in domestic livestock and tsetse flies from an insular endemic focus (Luba, Equatorial Guinea). [PDF]

, 2010
BACKGROUND: Sleeping sickness is spread over 36 Sub-Saharan African countries. In West and Central Africa, the disease is caused by Trypanosoma brucei gambiense, which produces a chronic clinical manifestation.
Abaga, Simón, Pedro Ndongo-Asumu, Ochando, Jordi, Ndong-Mabale Nicolás, Carmen García-Estébanez, Nicolás Ndong-Mabale, Ndong-Mabale, Nicolás, Agustín Benito, Carlos Cordon-Obras, Ndongo-Asumu, Pedro, Benito Agustín, García-Estébanez, Carmen, Cano, Jorge, Cordon-Obras, Carlos, Cano Jorge, Benito, Agustín, Cordon-Obras Carlos, Simón Abaga, Abaga Simón, Ndongo-Asumu Pedro, Jorge Cano, García-Estébanez Carmen   +21 more
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A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

The development of drugs for treatment of sleeping sickness: a historical review

Parasites & Vectors, 2010
Only four drugs are available for the chemotherapy of human African trypanosomiasis or sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. The history of the development of these drugs is well known and documented. suramin, pentamidine
Steverding Dietmar
doaj   +1 more source

NOTES ON SLEEPING SICKNESS. [PDF]

The Lancet, 1902
n ...
openaire   +2 more sources

Assessing the patterns of health-seeking behaviour and awareness among sleeping-sickness patients in eastern Uganda.

, 2004
For those with sleeping sickness, the consequences of delayed diagnosis include poor prognosis at treatment and an increased risk of tsetse infection. Data on their socio-demographic and clinical characteristics, health-seeking behaviour and delays in ...
Fèvre, EM, Odiit, M., McDermott, John J., Fèvre, Eric M., Shaw, A, Coleman, PG, Coleman, P.G., Welburn, SC, Welburn, S.C., McDermott, JJ, Shaw, Alison, Odiit, M   +11 more
core   +1 more source

Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness [PDF]

, 2012
Disruption of glycosylphosphatidylinositol biosynthesis is genetically and chemically validated as a drug target against the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness.
Michael A. J. Ferguson, Crossman, Arthur T., Abdelwahab, Nuha Z., Urbaniak, Mick, Ferguson, Michael A. J.; id_orcid, Arthur T. Crossman, Michael D. Urbaniak, Lauren Sullivan, Sullivan, Lauren, Urbaniak, Michael D., Nuha Z. Abdelwahab, Ferguson, Michael A J   +11 more
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Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial

Bulletin of the World Health Organization, 2000
OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ...
Jacques Pépin, Nzambi Khonde, Faustine Maiso, Félix Doua, Shabbar Jaffar, Stéphane Ngampo, Bokelo Mpia, Dawson Mbulamberi, Felix Kuzoe   +8 more
doaj  

Potential applicability of the importation risk index for predicting the risk of rarely imported infectious diseases

BMC Public Health, 2023
Background There have been many prediction studies for imported infectious diseases, employing air-travel volume or the importation risk (IR) index, which is the product of travel-volume and disease burden in the source countries, as major predictors ...
Kyung-Duk Min, Sun-Young Kim, Yoon Young Cho, Seyoung Kim, Joon-Sup Yeom   +4 more
doaj   +1 more source

Spatial and temporal risk factors for the early detection of Trypanosoma brucei rhodesiense sleeping sickness patients in Tororo and Busia districts, Uganda.

, 2004
We have carried out a study of risk factors for early detection of Trypanosoma brucei rhodesiense sleeping sickness. Records of sleeping sickness patients from 1987 to 2001 from Tororo and Busia districts in Uganda were reviewed for their village of ...
Fèvre, EM, Odiit, M., McDermott, John J., Woolhouse, Mark E.J., Fèvre, Eric M., Coleman, PG, Coleman, P.G., Welburn, SC, Welburn, S.C., McDermott, JJ, Woolhouse, MEJ, Odiit, M   +11 more
core   +1 more source