Results 81 to 90 of about 19,704 (280)
American Journal of Community Psychology, EarlyView.Abstract This study analyzes a participatory project to develop peer support services for people with serious mental illnesses (SMIs) in China. Drawing on interviews with psychiatrists, social workers, service users, and a family caregiver, it examines the conditions, challenges, facilitators, and outcomes of participation in a paternalistic context ...
Zhiying Ma +6 more
wiley +1 more source
Schizophrenia Genetics Modulates Clinical Depressive Features
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.
Alessandro Serretti +13 more
wiley +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Pathogenic variants in the SCN5A gene and its subunits have been identified in individuals with Brugada Syndrome. One such SCN5A variant, c.689T>C(p.Ile230Thr), was previously reported as disease‐causing only in homozygous individuals, with heterozygous carriers being unaffected.
Shayla Shojaat +2 more
wiley +1 more source
Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression
npj Precision Oncology, 2017 Esophageal cancer: African sleeping sickness drug shows activity against tumors Blocking an enzyme involved in the cellular synthesis of essential compounds called polyamines could help treat esophageal cancer.
Wei He +8 more
doaj +1 more source
Frontiers in Microbiology, 2015 The unicellular pathogenic protozoan Trypanosoma brucei gambiense is responsible for the chronic form of sleeping sickness. This vector-borne disease is transmitted to humans by the tsetse fly of the group Glossina palpalis, including the subspecies G. p.
Anne eGeiger +6 more
doaj +1 more source
Homology Modeling and Molecular Dynamics Study of NAD-Dependent Glycerol-3-Phosphate Dehydrogenase from Trypanosoma brucei rhodesiense, a Potential Target Enzyme for Anti-Sleeping Sickness Drug Development [PDF]
, 2002 Igor Z. Zubrzycki
openalex +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt +9 more
wiley +1 more source
Human African Trypanosomiasis (Sleeping Sickness)-Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention. [PDF]
Curr Trop Med Rep, 2023 Ortiz-Martínez Y +4 more
europepmc +1 more source
A voluntary use of insecticide-treated cattle can eliminate African sleeping sickness [PDF]
, 2015 Kira Crawford +3 more
openalex +1 more source