Results 41 to 50 of about 7,458 (253)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Krein–Langer Factorization and Related Topics in the Slice Hyperholomorphic Setting [PDF]

open access: yesThe Journal of Geometric Analysis, 2012
Version to appear in the Journal of Geometric ...
D. Alpay   +2 more
openaire   +4 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Match-Unity: Long-Form Text Matching With Knowledge Complementarity

open access: yesIEEE Access
Semantic text matching is a fundamental task in Natural Language Processing, with existing methods mainly focusing on short texts. However, handling long texts remains a challenge, as conventional approaches often involve slicing or keyword filtering ...
Zhiyi He   +6 more
doaj   +1 more source

Sliced Inverse Regression and Independence in Random Marked Sets with Covariates [PDF]

open access: yesAdvances in Applied Probability, 2013
Dimension reduction of multivariate data was developed by Y. Guan for point processes with Gaussian random fields as covariates. The generalization to fibre and surface processes is straightforward. In inverse regression methods, we suggest slicing based on geometrical marks.
Šedivý, Ondřej}   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

External rays and the real slice of the Mandelbrot set [PDF]

open access: yesErgodic Theory and Dynamical Systems, 2003
22 pages, 4 ...
openaire   +2 more sources

A general criterion for jump set slicing and applications

open access: yes, 2022
In this paper a novel criterion for the slicing of the jump set of a function is provided, which bypasses the codimension-one and the parallelogram law techniques developed in $BD$-spaces. The approach builds upon a recent rectifiability result of integralgeometric measures and is further applied to the study of the structure of the jump set of ...
Almi, Stefano, Tasso, Emanuele
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy