Results 121 to 130 of about 323,696 (314)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Bond tilting and sliding friction in a model of cell adhesion

, 2007
As a simple theoretical model of a cell adhering to a biological interface, we consider a rigid cylinder moving in a viscous shear flow near a wall. Adhesion forces arise through intermolecular bonds between receptors on the cell and their ligands on the
Jensen, O. E.; id_orcid, Reboux, S., Richardson, Giles, Jensen, O.E., Richardson, G.   +4 more
core   +1 more source

Sliding dynamics induced by periodic frictional driving

Friction
We investigate the frictional dynamics experienced by a free mass placed on a harmonically oscillating surface. Unlike traditional setups used to study frictional instabilities such as stick-slip oscillations, where a mass attached to a wall by a spring ...
Martin Maza-Cuello, Diego Maza
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Sliding-mode-based robust output regulation and its application in PMSM servo systems

, 2022
A robust output regulation of a control system aims at disturbance rejection and reference tracking in the presence of uncertainties. Technically, the control design contains two mechanisms: the compensation of nontrivial steady states caused by ...
Jun Yang (4410343), Lu Zhang (50563), Shihua Li (737625), Zhiyong Chen (502397), Xinghuo Yu (623402)   +4 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

METHOD FOR TREATING A SLIDING SURFACE OF A SLIDING DEVICE AND THE SLIDING DEVICE COMPRISING THAT SLIDING SURFACE

, 2017
Method for treating a base (11) able to be used in a sliding apparatus (10) and provided with at least a sliding surface (21); the method comprises at least a first step of cutting the base (11) by means of which a plurality of craters (22) with a controlled depth (P) and diameter (D) are made on the sliding surface (21), and at least a second step of ...
P. M. Ossi, F. Ripamonti, M. F. Moro
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Computational Analysis of Wall Slip and Cavitation in Lubricated Sliding Systems [PDF]

, 2012
Lubrication is applied to systems in which parts are in relative motion to avoid direct contact between the surfaces. The behavior of the fluid-film in sliding bearings depends on the boundary conditions at the interface between the liquid and the ...
M, Muchammad, D.J. , Schipper, J. , Jamari, M. , Tauviqirrahman   +3 more
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source