Results 51 to 60 of about 323,696 (314)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Robust sliding mode design for uncertain stochastic systems based on H∞ control method

, 2009
The official published version can be found at the link below.In this paper, the design problem of sliding mode control (SMC) is addressed for uncertain stochastic systems modeled by Itô differential equations.
Wang, X, Zidong Wang, Wang, Z, Niu, Y, Yugang Niu, Xingyu Wang   +5 more
core   +1 more source

Presence of Calcium Lowers the Expansion of Bacillus subtilis Colony Biofilms

Microorganisms, 2017
Robust colony formation by Bacillus subtilis is recognized as one of the sessile, multicellular lifestyles of this bacterium. Numerous pathways and genes are responsible for the architecturally complex colony structure development.
Eisha Mhatre, Anandaroopan Sundaram, Theresa Hölscher, Mike Mühlstädt, Jörg Bossert, Ákos T. Kovács   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sliding wear of a-C:H coatings against alumina in corrosive media [PDF]

, 2013
This paper reports the results obtained from the study of friction and sliding wear in two corrosive solutions of an a-C:H coating deposited on 316L stainless against an alumina ball, employed as static counter part. Calculations of the values of the von
La Barbera Sosa, J.G., PUCHI-CABRERA, Eli-Saul, IOST, Alain, Santana Mendez, Y.Y., PUCHI-CABRERA, E.S., CHICOT, Didier, CHICOT, D., van Gorp, A., SANTANA, Y.Y., VAN GORP, Adrien, Carrasquero, E.J., Iost, A., STAIA, M.H., Puchi-Cabrera, Eli Saúl, CARRASQUERO, E., LA BARBERA-SOSA, J.G., Santana-Mendez, Y.Y.   +16 more
core   +1 more source

Law of Friction: from Tribology to Tribo-Fatigue. Report 1. Classical Law of (Dry) Friction and Need for its Adjustment

Механика машин, механизмов и материалов, 2019
To date, many laws of Nature have been discovered. The knowledge of each of them led to the accelerated development of the relevant sections of Science and further, as a rule, to progress in any practical area of the community of people. The empirical
Leonid A. Sosnovskiy
doaj  

Softness Perception Interfered by Friction in Gliding Virtual Surfaces

IEEE Access
Recent studies have shown that surface friction affects softness perception when objects are slid over using fingers. This study examines whether this phenomenon extends to interactions with virtual objects using a stylus-based haptic interface, which ...
Hongbo Wang, Shogo Okamoto
doaj   +1 more source

Design sizing of cylindrical worm gearsets [PDF]

FME Transactions, 2020
A method for the design sizing task of cylindrical worm gearsets is presented that gives an estimate of the initial value of the normal module. Expressions are derived for the worm pitch diameter of integral and shell worms as well as for the active face
Osakue Edward E., Anetor Lucky
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Arnol′d tongues arising from a grazing-sliding bifurcation

, 2009
The Neımark–Sacker bifurcation, or Hopf bifurcation for maps, is a well-known bifurcation for smooth dynamical systems. At this bifurcation a periodic orbit loses stability, and, except at certain “strong” resonances, an invariant torus is born.
Osinga, HM, Szalai, Róbert, Osinga, Hinke, Szalai, R   +3 more
core   +1 more source