Results 101 to 110 of about 910,363 (405)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Global robust super-twisting algorithm with adaptive switching gains for a hybrid robot

International Journal of Advanced Robotic Systems, 2020
To improve the robustness performance of dynamic sliding mode control to the time-varying uncertainties without the upper bound information in a hybrid robot system, a global robust super-twisting algorithm with adaptive switching gains is proposed.
Guoqin Gao, Songyun Zhang, Mengyang Ye
doaj   +1 more source

An Adaptive Backstepping Nonsingular Fast Terminal Sliding Mode Control for Robust Fault Tolerant Control of Robot Manipulators

IEEE Transactions on Systems, Man, and Cybernetics: Systems, 2019
This paper develops a novel control methodology for tracking control of robot manipulators based on a novel adaptive backstepping nonsingular fast terminal sliding mode control (ABNFTSMC).
Mien Van, M. Mavrovouniotis, S. Ge
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Convergence rate sliding mode control of permanent magnet synchronous motor based on expanded sliding mode observer

Journal of Engineering and Applied Science
The aim is to address the limitations of conventional sliding mode control for PMSM, namely the problems of sliding mode oscillation, load disturbance, and poor control accuracy. An improved sliding mode control strategy for PMSM is proposed based on the
Li Tian, Qingrui Wei, Qiang Zheng, Hailong Li   +3 more
doaj   +1 more source

Sliding Mode Control System of Single Phase Buck-Boost Inverter with Buffer Inductor [PDF]

, 2015
Inverter is one of the primary components of a distributed electric power plants that serve as modifiers DC voltage into AC. In this research is applied of the Sliding Mode Control on Inverter Buck Boost One phase with Buffer Inductor.
Abdurrakhman, A. (Arief), Darwito, P. A. (Purwadi), Fachrullah, A. (Almas)   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enhanced Fuzzy Sliding Mode Control to MotionController of Linear Induction Motor Drives [PDF]

[[abstract]]In this paper, an enhanced fuzzy sliding mode control system (EFSMC) is proposed for a linear induction motor (LIM) to achieve the position tracking.
Hsu, Kou-Cheng
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Adaptive sliding mode control for uncertain airplane control systems based on higher-order differential sliding mode surface

Journal of Hebei University of Science and Technology, 2018
Airplane control system is a typical multitude input and multitude output (MIMO) nonlinear system with strong coupling and uncertainties, which would increase the controlling difficulty.
Xiaojing WU, Xueli WU, Shikai SHAO, Huixian LIU   +3 more
doaj   +1 more source