Results 91 to 100 of about 57,343 (306)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sliding-Mode Observer for Speed and Position Sensorless Control of Linear-PMSM

Electrical, Control and Communication Engineering, 2014
The paper presents a sliding-mode observer that utilizes sigmoid function for speed and position sensorless control of permanent-magnet linear synchronous motor (PMLSM). In conventional sliding mode observer method there are the chattering phenomenon and
Kazraji Saeed Masoumi, Soflayi Ramin Bavili, Sharifian Mohammad Bagher Bannae   +2 more
doaj   +1 more source

Fault detection and fault-tolerant control of a civil aircraft using a sliding-mode-based scheme [PDF]

, 2015
Journal ArticleThis paper presents a sliding-mode approach for fault-tolerant control of a civil aircraft, where both actuator and sensor faults are considered.
Alwi, Halim, Edwards, Christopher
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

State of Charge Estimation for Power Lithium-Ion Battery Using a Fuzzy Logic Sliding Mode Observer

Energies, 2019
State of charge (SOC) estimation is of vital importance for the battery management system in electric vehicles. This paper proposes a new fuzzy logic sliding mode observer for SOC estimation.
Wenhui Zheng, Bizhong Xia, Wei Wang, Yongzhi Lai, Mingwang Wang, Huawen Wang   +5 more
doaj   +1 more source

Adaptive Backstepping Sliding Mode Control of the Hybrid Conveying Mechanism with Mismatched Disturbances via Nonlinear Disturbance Observers

Journal of Control Science and Engineering, 2020
An adaptive backstepping sliding mode controller combined with a nonlinear disturbance observer is designed for trajectory tracking of the electrically driven hybrid conveying mechanism with mismatched disturbances.
Wei Yuan, Guoqin Gao, Jianzhen Li
doaj   +1 more source

HOSM State Estimation and Robust PID Control of a Chemical Process [PDF]

, 2012
This paper presents some results of the authors’ studies on robust estimation and control for chemical processes. Here, an observer-based controller is designed for a chemical process.
Botero-Castro, Héctor, Giraldo, Bertulfo, Sánchez-Torres, Juan D.   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Observer–Based Sliding–Mode Fault–Tolerant Consistent Control for Hybrid Event–Triggered Multi–Agent Systems

International Journal of Applied Mathematics and Computer Science
An observer-based hybrid event-triggered sliding mode fault-tolerant consistent control strategy is proposed for actuator faults in nonlinear second-order leader–follower multi-agent systems.
Xia Dexian, Fu Xingjian
doaj   +1 more source